299-28-5Relevant articles and documents
Crystal structure and thermodynamic properties of the coordination compound calcium D-gluconate Ca[D-C6H11O7]2(s)
Di, You-Ying,Kong, Yu-Xia,Liu, Yu-Pu,Zhang, Guo-Chun,Zhou, Chun-Sheng
, (2020/09/03)
The coordination compound calcium D-gluconate, Ca[D-C6H11O7]2(s), was synthesized and characterized by chemical analysis, elemental analysis, and X-ray crystallography. Single crystal X-ray diffraction technique revealed that the compound was formed by two D-gluconate anions and one calcium (II) cation. And the D-gluconate anion had a curved chain configuration with an intramolecular bond. The compound exhibited an outstanding chelate property of D-gluconate anions to calcium (II) cations, and the calcium (II) cation was eight-coordinated and chelated by four D-gluconate anions. The lattice potential energy and ionic volume of the anion were calculated to be 1434.05 kJ?mol?1 and 0.4211 nm3 from crystallographic data. In accordance with famous Hess law, a reasonable thermochemical cycle was designed and the standard molar enthalpy of formation of Ca[D-C6H11O7]2(s) was calculated as ΔsHm[Ca[D-C6H11O7]2, s] = -(3545.19 ± 1.07) kJ?mol?1 by use of an isoperibol solution-reaction calorimeter. Furthermore, molar heat capacities of the compound were measured using a Quantum Design Physical Properties Measurement System (PPMS) with specific heat option within the temperature range from (1.9–300) K. The heat capacities of the compound increased with the temperature and no thermal anomaly was found in the whole temperature region. The experimental data was fitted to a function of the absolute temperature T with a series of theoretical and empirical models for the proper temperature ranges. The values of standard thermodynamic function, Cp,mo/J?K?1?mol?1, Δ0THmo/kJ?mol?1, Δ0TSmo/J?K?1?mol?1, and ΔoTGmo/T/J?K?1?mol?1 (=Δ0TSmo-Δ0THmo/T) from T = (0–300) K was calculated based on the fitting results. The standard molar heat capacity, entropy and enthalpy of the compound at T = 298.15 K and 0.1 MPa was determined to be Cp,mo= (493.20 ± 2.70) J·K?1 mol?1, Hmo= (75934 ± 805) J·mol?1, Smo= (471.55 ± 2.78) J·K?1 mol?1, and Gmo/T = - (64658 ± 808) J·K?1?mol?1, respectively.
Preparation method of calcium glucarate
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Paragraph 0051-0054, (2019/05/08)
The invention relates to a preparation method of calcium glucarate, and belongs to the field of pharmacy. The invention provides a preparation method of the calcium glucarate. The preparation method comprises the following steps: (1) putting glucose, oxygen and a metal catalyst palladium vanadium ammonium into a high-pressure reactor for catalytic oxidation reaction to obtain glucaric acid; (2) after the oxidation reaction, adding potassium-containing alkali to convert the glucaric acid into potassium gluconate; (3) enabling the potassium gluconate to react with an acid to release the glucaricacid; (4) enabling the glucaric acid to react with the calcium-containing alkali to obtain the calcium glucarate. The preparation method disclosed by the invention is pollution-free to the environment, and meanwhile, the total yield is increased; the catalyst can be repeatedly used; the cost is reduced; the calcium content is 98 to 102 percent; a small amount of industrial wastewater, waste residues and waste gas are generated; the preparation method is suitable for industrial production.
BIOLOGICALLY ACTIVE FOOD ADDITIVE FOR THE PROPHYLAXIS OF OSTEOPOROSIS DISEASE
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, (2012/10/08)
The invention relates to biologically active food supplements and is intended for preventive action against the states associated with osteoporosis. The technical effect consists in providing a biologically active food supplement which sustains a normal testosterone level in the body, ensures an efficient assimilation of calcium by the body and retention of calcium in the bony tissue for a prolonged time enabling thereby the prevention of osteoporosis.
