29910-92-7

Basic information

• Product Name: 3-(4-methoxyphenyl)-1H-isochromen-1-one
• Synonyms: 1H-2-benzopyran-1-one, 3-(4-methoxyphenyl)-; 3-(4-Methoxyphenyl)-1H-isochromen-1-one
• CAS NO: 29910-92-7
• Molecular Formula: C₁₆H₁₂O₃
• Molecular Weight: 252.2647
• Mol File: 29910-92-7.mol
• Article Data: 50

Chemical Properties

• Boiling Point: 414.5°C at 760 mmHg
• Flash Point: 176°C
• Density: 1.24g/cm³
• Vapor Pressure: 4.43E-07mmHg at 25°C
• Refractive Index: 1.614
• CAS DataBase Reference: 3-(4-methoxyphenyl)-1H-isochromen-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-methoxyphenyl)-1H-isochromen-1-one(29910-92-7)
• EPA Substance Registry System: 3-(4-methoxyphenyl)-1H-isochromen-1-one(29910-92-7)

Safety Data

• Hazardous Substances Data: 29910-92-7(Hazardous Substances Data)

Upstream product

• 95280-73-2 methyl 2-(2-(4-methoxyphenyl)-2-oxoethyl) benzoate 
• 14593-46-5 sodium tert-pentoxide 
• 108-88-3 toluene 
• 130818-20-1 2-(2-(4-methoxyphenyl)ethynyl)benzoic acid methyl ester 
• 6630-33-7 ortho-bromobenzaldehyde 
• 768-60-5 4-methoxyphenylacetylen 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 859829-95-1 2-((4-methoxyphenyl)ethynyl)benzoic acid 
• 88-67-5 2-Iodobenzoic acid 
• 78610-84-1 1-phenyl-1λ³-benzo[d][1,2]iodaoxol-3(1H)-one 
• 33675-41-1 1-bromo-2-(4-methoxyphenyl)acetylene 
• 65-85-0 benzoic acid 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 88-65-3 2-bromobenzoic-acid 

Downstream Products

• 71568-78-0 8,3'-Deoxythunberginol A 
• 92964-70-0 3-(4-methoxyphenyl)-1H-isochromene-1-thione 
• 28352-56-9 4-(4-methoxyphenyl)-2,5-dihydro-5H-2,3-benzodiazepin-1-one 
• 80458-97-5 3,4-dihydro-3-(4-hydroxyphenyl)-1H-2-benzopyran-1-one 
• 95280-73-2 methyl 2-(2-(4-methoxyphenyl)-2-oxoethyl) benzoate 
• 37568-81-3 3,4-dihydro-3-(4-methoxyphenyl)-1H-2-benzopyran-1-one 
• 33533-90-3 2-[2-oxo-2-(4'-methoxyphenyl)ethyl]benzoic acid 

Relevant articles and documents

Functionalized 2'-carboxamidodeoxybenzoins by ring opening of 3-aryl-1H-isochromen-1-ones with secondary amines

[Figure not available: see fulltext.] An efficient approach based on pyrone ring opening in 3-arylisocoumarins in the presence of cyclic secondary amines was developed in order to prepare amides of deoxybenzoin-2'-carboxylic acids, diverse functionalized

Triflic acid mediated sequential cyclization of ortho-alkynylarylesters with ammonium acetate

A triflic acid (TfOH) mediated sequential cyclization of ortho-alkynylarylesters and ammonium acetate (NH4OAc) was reported. The reaction took place via a Br?nsted acid-mediated intramolecular cyclization of ortho-alkynylarylesters followed by an ammonium acetate participated substitution reaction, forming isoquinolin-1-ones as the major products. Different from most of the known synthetic methods of isoquinolin-1-ones, no metal catalyst was required in the reported reaction. The regioisomers – isoindolin-1-ones were obtained together with isoquinolin-1-ones in a few cases. The intermediate compounds – isochromen-1-ones and isobenzofuran-1-ones were also isolated. The interconversion experiments showed that the regioisomers formed during the Br?nsted acid induced intramolecular cyclization of ortho-alkynylarylesters. A natural product – ruprechstyril was prepared in a moderate yield employing the new method.

Fluorination-triggered tandem cyclization of styrene-type carboxylic acids to access 3-aryl isocoumarin derivatives under microwave irradiation

A practical and straightforward synthetic route through a fluorination-triggered tandem cyclization of styrene-type carboxylic acids was developed to construct a variety of 4-fluoro-3-aryl-3,4-dihydroisocoumarins and 3-arylisocoumarins under microwave irr