300386-87-2

Basic information

• Product Name: (5beta,7alpha,12alpha)-7,12-Bis(acetyloxy)-3-oxocholan-24-oic acid
• Synonyms: (5beta,7alpha,12alpha)-7,12-Bis(acetyloxy)-3-oxocholan-24-oic acid;3-oxo-7α,12α-diforMyloxy-5β-cholan-24-oic acid;(5β,7α,12α)-7,12-Bis(acetyloxy)-3-oxocholan-24-oic acid;3-Oxo-7a,12a-diforMyloxy-5b-cholanic acid
• CAS NO: 300386-87-2
• Molecular Formula: C₂₈H₄₂O₇
• Molecular Weight: 490.62888
• Mol File: 300386-87-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.18
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (5beta,7alpha,12alpha)-7,12-Bis(acetyloxy)-3-oxocholan-24-oic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (5beta,7alpha,12alpha)-7,12-Bis(acetyloxy)-3-oxocholan-24-oic acid(300386-87-2)
• EPA Substance Registry System: (5beta,7alpha,12alpha)-7,12-Bis(acetyloxy)-3-oxocholan-24-oic acid(300386-87-2)

Safety Data

• Hazardous Substances Data: 300386-87-2(Hazardous Substances Data)

Usage

General Description

(5beta,7alpha,12alpha)-7,12-Bis(acetyloxy)-3-oxocholan-24-oic acid is a chemical compound known as acetylsalicylic acid, commonly referred to as aspirin. It is a nonsteroidal anti-inflammatory drug (NSAID) that is often used to reduce pain, fever, and inflammation. Aspirin works by inhibiting the production of certain chemicals in the body that cause pain and inflammation. It is also used for its antiplatelet effects, which can help prevent blood clots and reduce the risk of heart attacks and strokes. Aspirin is a widely used and well-known medication that has been used for decades to treat a variety of conditions.

Upstream product

• 4947-65-3 methyl 3-keto-7,12-diacetylcholate 
• 14772-99-7 3-oxo cholic acid methyl ester 
• 81-25-4 cholic acid 
• 6818-44-6 methyl 3,7,12-triacetoxycholan-24-oate 
• 1448-36-8 methyl cholate 
• 69889-89-0 methyl 7,12-diacetoxycholate 
• 2304-89-4 7α,12α-dihydroxy-3-oxocholanoic acid 
• 108-24-7 acetic anhydride 
• 61543-86-0 3α-hydroxy-7α,12α-diacetoxy-5β-cholan-24-oic acid 

Downstream Products

• 13535-96-1 3-oxo-12α-hydroxy-4,6-choladien-24-oic acid 

Relevant articles and documents

Cholic acid derivatives as 1,2,4,5-tetraoxane carriers: Structure and antimalarial and antiproliferative activity

Cholic acid-derived 1,2,4,5-tetraoxanes were synthesized in order to explore the influence of steroid carrier on its antimalarial and antiproliferative activity in vitro. Starting with chiral ketones, cis and trans series of diastereomeric tetraoxanes were obtained, and the cis series was found to be ~2 times as active as the trans against Plasmodium falciparum D6 and W2 clones. The same tendency was observed against human melanoma (Fem-X) and human cervix carcinoma (HeLa) cell lines. The amide C(24) termini, for the first time introduced into the carrier molecule of a tetraoxane pharmacophore, significantly enhanced both antimalarial and antiproliferative activity, as compared to the corresponding methyl esters, with cis-bis(N-propylamide) being most efficient against the chloroquine-susceptible D6 clone (IC50 = 9.29 nM). cis- and trans-bis(N-propylamides) were also screened against PBMC, and PHA-stimulated PBMC, showing a cytotoxicity/antimalarial potency ratio of 1/10 000.