30144-12-8

Basic information

• Product Name: 1,3,4-trimethyl-1H-pyrrole
• Synonyms: Pyrrole, 1,3,4-trimethyl-
• CAS NO: 30144-12-8
• Molecular Formula: C₇H₁₁N
• Molecular Weight: 109.1689
• Mol File: 30144-12-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 164.6°C at 760 mmHg
• Flash Point: 53.4°C
• Density: 0.87g/cm³
• Vapor Pressure: 2.56mmHg at 25°C
• Refractive Index: 1.484
• CAS DataBase Reference: 1,3,4-trimethyl-1H-pyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,4-trimethyl-1H-pyrrole(30144-12-8)
• EPA Substance Registry System: 1,3,4-trimethyl-1H-pyrrole(30144-12-8)

Safety Data

• Hazardous Substances Data: 30144-12-8(Hazardous Substances Data)

Upstream product

• 112950-86-4 5-methyl-(3ar,6ac)-hexahydro-thieno[3,4-c]pyrrole 
• 822-51-5 3,4-dimethyl-1H-pyrrole 
• 74-88-4 methyl iodide 
• 80-48-8 methyl p-toluene sulfonate 
• 7732-18-5 water 
• 101448-83-3 thiophene-3,3,4,4-tetracarboxylic acid tetraethyl ester 
• 16810-52-9 cis-3,4-dicarboxythiacyclopentane anhydride 
• 105526-69-0 5-methyl-(3ar,6ac)-tetrahydro-thieno[3,4-c]pyrrole-4,6-dione 

Downstream Products

• 60205-12-1 1,3,4-trimethyl-1,5-dihydro-2H-pyrrol-2-one 

Relevant articles and documents

Structure-activity relationship studies on (4-acylpyrrol-2-yl)alkanoic acids as inhibitors of the cytosolic phospholipase A2: Variation of the alkanoic acid substituent, the acyl chain and the position of the pyrrole nitrogen

(4-Acylpyrrol-2-yl)alkanoic acid derivatives were prepared and evaluated for their ability to inhibit the cytosolic phospholipase A2 of intact bovine platelets. To define the structural requirements for enzyme inhibition, the alkanoic acid group, the acyl residue and the position of the pyrrole nitrogen relative to the pyrrole substituents were varied systematically. Inhibition of cPLA2 was best by compounds containing a free acetic acid or propionic acid group and an acyl chain of 12 or more carbons. The position of the pyrrole nitrogen did not influence the activity significantly. One of the most potent of the cPLA2 inhibitors synthesized was (1,3,5-trimethyl-4- octadecanoylpyrrol-2-yl)acetic acid (IC50:10 μM).