30169-34-7

Basic information

• Product Name: Quinazoline, 6-chloro-2,4-diphenyl-
• CAS NO: 30169-34-7
• Molecular Formula: C20H13ClN2
• Molecular Weight: 316.79
• Mol File: 30169-34-7.mol
• Article Data: 34

Chemical Properties

• CAS DataBase Reference: Quinazoline, 6-chloro-2,4-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinazoline, 6-chloro-2,4-diphenyl-(30169-34-7)
• EPA Substance Registry System: Quinazoline, 6-chloro-2,4-diphenyl-(30169-34-7)

Safety Data

• Hazardous Substances Data: 30169-34-7(Hazardous Substances Data)

Upstream product

• 75092-48-7 6-Chlor-3-(4-chlorphenyl)-3,4-dihydro-2,4-diphenyl-4-hydroxychinazolin 
• 5922-60-1 2-amino-5-chlorobenzonitrile 
• 98-88-4 benzoyl chloride 
• 84570-94-5 6-Chloro-2,4-diphenyl-1,2,3,4-tetrahydro-quinazoline 
• 7664-41-7 ammonia 
• 100-47-0 benzonitrile 
• 21259-25-6 N-Benzoyl-2-amino-5-chlorobenzophenone 
• 106-47-8 4-chloro-aniline 
• 719-59-5 5-chloro-2-aminobenzophenone 
• 100-46-9 benzylamine 
• 100-52-7 benzaldehyde 
• 6628-86-0 5-chloro-2-nitrobenzaldehyde 
• 20028-53-9 2-amino-5-chlorobenzaldehyde 
• 2835-06-5 phenylglycin 

Relevant articles and documents

A convenient access to 2,4-disubstituted quinazolines via one-pot three-component reaction under mild conditions?

A new and practical method has been developed for the synthesis of 2,4-disubstituted quinolines via one-pot three-component reaction of o-amino arylketones, aldehydes and ammonium acetate in high yields by using DDQ in CH3CN under mild conditio

TMSOTf-catalyzed synthesis of substituted quinazolines using hexamethyldisilazane as a nitrogen source under neat and microwave irradiation conditions

In this article, we report an efficient and mild synthetic route for the construction of substituted quinazolines from functionalized 2-aminobenzophenones with various benzaldehydes usingcat. TMSOTf and hexamethyldisilazane (HMDS) under neat, metal-free and microwave irradiation conditions in which gaseous ammonia was formedin situ. This synthetic protocol provided the desired quinazolines with a broad substrate scope in good to excellent yields. Some structures were confirmed by X-ray single-crystal diffraction analysis.

Molecular Iodine Catalysed Benzylic sp 3 C-H Bond Amination for the Synthesis of 2-Arylquinazolines from 2-Aminobenzaldehydes, 2-Aminobenzophenones and 2-Aminobenzyl Alcohols

Molecular iodine catalysed benzylic sp 3 C-H bond amination has been developed for the synthesis of quinazolines from 2-aminobenzaldehydes and 2-aminobenzophenones with benzylamines. The use of oxygen as a green oxidant combined with the transition-metal-, additive- and solvent-free conditions makes the methodology economical and greener. The lack of aqueous work up also enhances the efficiency of this protocol. A series of 2-arylquinazolines was synthesised in good to excellent yields by using the developed protocol. 2-Aminobenzyl alcohols could also be employed to prepare the corresponding quinazoline derivatives.