305849-49-4

Basic information

• Product Name: Benzeneacetamide, N-[(4-methoxyphenyl)methyl]-
• CAS NO: 305849-49-4
• Molecular Formula: C16H17NO2
• Molecular Weight: 255.316
• Mol File: 305849-49-4.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Benzeneacetamide, N-[(4-methoxyphenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetamide, N-[(4-methoxyphenyl)methyl]-(305849-49-4)
• EPA Substance Registry System: Benzeneacetamide, N-[(4-methoxyphenyl)methyl]-(305849-49-4)

Safety Data

• Hazardous Substances Data: 305849-49-4(Hazardous Substances Data)

Upstream product

• 103-81-1 Benzeneacetamide 
• 105-13-5 4-Methoxybenzyl alcohol 
• 60-12-8 2-phenylethanol 
• 70978-37-9 1-(azidomethyl)-4-methoxybenzene 
• 623-12-1 4-chloromethoxybenzene 
• 2393-23-9 4-methoxy-benzylamine 
• 103-82-2 phenylacetic acid 
• 103-80-0 phenylacetyl chloride 

Downstream Products

• 550310-37-7 4-methoxy-N-(2-phenylacetyl)benzamide 
• 330580-67-1 3,4-dihydro-3-[4-methoxybenzyl(phenylacetyl)amino]-2-oxobenz[e][1,3]oxazine-7-carboxylic acid 
• 330580-66-0 3-hydroxy-4-{[2-(4-methoxybenzyl)-2-(phenylacetyl)hydrazino]methyl}benzoic acid 
• 330580-65-9 3-hydroxy-4-{[2-(4-methoxybenzyl)-2-(phenylacetyl)hydrazono]methyl}benzoic acid 
• 330580-68-2 3,4-dihydro-3-[(phenylacetyl)amino]-2-oxo-2H-1,3-benzoxazine-7-carboxylic acid 
• 330580-64-8 1-(4-methoxybenzyl)-1-phenylacetylhydrazine 
• 1027199-44-5 C₁₆H₁₆N₂O₃ 

Relevant articles and documents

Direct amidation of non-activated carboxylic acid and amine derivatives catalyzed by TiCp2Cl2

This paper described a mild and efficient direct amidation of non-activated carboxylic acid and amine derivatives catalyzed by TiCp2Cl2. Arylacetic acid derivatives reacted with different amines to afford the corresponding amides in good to excellent yield except of aniline. Aryl formic acids failed to react with aniline but smoothly reacted with aliphatic amines and benzylamine in moderate to good yield, fatty acids reacting with benzyl and aliphatic amines give amides in good to excellent yield. Chiral amino acids derivatives were transformed into amides without racemization in moderate yield. The possible mechanism of direct amidation catalyzed by TiCp2Cl2 was discussed. This catalytic method is very suitable for the amidation of low sterically hindered arylacetic acid, fatty acids with different low sterically hindered amines except aniline, as well as the amidation of aryl formic acid with benzyl and aliphatic amines.

Latent Bronsted Base Solvent-Assisted Amide Formation from Amines and Acid Chlorides

Weakly basic amines, including even neutral amines such as nitroaniline and aminocarboxylic acids, react with acid chlorides very efficiently in N, N -dimethylacetamide (DMAC), without addition of a base, to give the corresponding amides in high yields. The role of DMAC and related solvents as latent Bronsted bases was studied in these amidation reactions. Less basic amines, such as aromatic amines, reacted with benzoyl chloride faster than more basic aliphatic amines.

2-Furanylboronic acid as an effective catalyst for the direct amidation of carboxylic acids at room temperature

2-Furanylboronic acid has been identified as an inexpensive and effective catalyst for the dehydrative amide formation of carboxylic acids and amines. This transformation can be efficiently carried out at room temperature and is applicable to a wide range of carboxylic acids with primary and secondary amines to afford amides in good to excellent yields.