306298-23-7 Usage
General Description
2-Methoxy-1-(4-(trifluoroMethyl)phenyl)ethanol is a chemical compound with the formula C10H12F3NO2. It is a colorless, odorless liquid that is used as a solvent, in organic synthesis, and as a reagent in chemical reactions. The compound is a derivative of phenyl ethanol, with a methoxy group and a trifluoromethyl group attached to the phenyl ring. It is also known by the trade name "4-(Trifluoromethyl)Phenyl Glycidyl Ether" and has a molecular weight of 227.20 g/mol. This chemical can pose health hazards and should be handled with care, following proper safety protocols and guidelines.
Check Digit Verification of cas no
The CAS Registry Mumber 306298-23-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,6,2,9 and 8 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 306298-23:
(8*3)+(7*0)+(6*6)+(5*2)+(4*9)+(3*8)+(2*2)+(1*3)=137
137 % 10 = 7
So 306298-23-7 is a valid CAS Registry Number.
InChI:InChI=1S/C10H11F3O2/c1-15-6-9(14)7-2-4-8(5-3-7)10(11,12)13/h2-5,9,14H,6H2,1H3
306298-23-7Relevant articles and documents
Tandem Acid/Pd-Catalyzed Reductive Rearrangement of Glycol Derivatives
Ciszek, Benjamin,Fleischer, Ivana,Kathe, Prasad,Schmidt, Tanno A.
supporting information, p. 3641 - 3646 (2020/03/25)
Herein, we describe the acid/Pd-tandem-catalyzed transformation of glycol derivatives into terminal formic esters. Mechanistic investigations show that the substrate undergoes rearrangement to an aldehyde under [1,2] hydrogen migration and cleavage of an oxygen-based leaving group. The leaving group is trapped as its formic ester, and the aldehyde is reduced and subsequently esterified to a formate. Whereas the rearrangement to the aldehyde is catalyzed by sulfonic acids, the reduction step requires a unique catalyst system comprising a PdII or Pd0 precursor in loadings as low as 0.75 mol % and α,α′-bis(di-tert-butylphosphino)-o-xylene as ligand. The reduction step makes use of formic acid as an easy-to-handle transfer reductant. The substrate scope of the transformation encompasses both aromatic and aliphatic substrates and a variety of leaving groups.
