306936-77-6

Basic information

• Product Name: 1,3-DIMETHYL-1H-PYRAZOLE-5-CARBONITRILE
• Synonyms: 1H-Pyrazole-5-carbonitrile,1,3-dimethyl-(9CI);1,3-Dimethyl-1H-pyrazole-5-carbonitrile ,98%;5-Cyano-1,3-dimethyl-1H-pyrazole;1H-Pyrazole-5-carbonitrile, 1,3-dimethyl-;2,5-Dimethyl-2H-pyrazole-3-carbonitrile
• CAS NO: 306936-77-6
• Molecular Formula: C6H7N3
• Molecular Weight: 121.14
• EINECS: 1592732-453-0
• Product Categories: NITRILE
• Mol File: 306936-77-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 248.7°C at 760 mmHg
• Flash Point: 104.2°C
• Appearance: /
• Density: 1.09g/cm³
• Vapor Pressure: 0.0238mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: -0.06±0.10(Predicted)
• CAS DataBase Reference: 1,3-DIMETHYL-1H-PYRAZOLE-5-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-DIMETHYL-1H-PYRAZOLE-5-CARBONITRILE(306936-77-6)
• EPA Substance Registry System: 1,3-DIMETHYL-1H-PYRAZOLE-5-CARBONITRILE(306936-77-6)

Safety Data

• Statements: 34-36/37/38
• Safety Statements: 26-27-36/37/39-45
• Hazardous Substances Data: 306936-77-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H7N3/c1-5-3-6(4-7)9(2)8-5/h3H,1-2H3

Upstream product

• 5744-56-9 1,3-dimethylpyrazol-5-carboxylic acid 
• 5744-40-1 ethyl 1,3-dimethylpyrazole-5-carboxylate 
• 4027-57-0 ethyl 5-methyl-2H-pyrazole-3-carboxylate 
• 25016-09-5 1,3-dimethyl-1H-pyrazole-5-carbaldehyde 
• 136678-93-8 1,3-dimethyl-1H-pyrazole-5-carboxamide 

Downstream Products

• 1454846-35-5 (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile 
• 1454848-24-8 ((4-bromo-5-cyano-1-methyl-1H-pyrazol-3-yl)methyl)(methyl)carbamic acid tert-butyl ester 
• 499770-63-7 1-(1,3-dimethyl-1H-pyrazol-5-yl)methanamine 
• 79080-36-7 2-cyano-1,4-dimethylimidazole 
• 19225-94-6 5-Cyan-1,2-dimethyl-imidazol 

Relevant articles and documents

MACROCYCLIC COMPOUNDS

Disclosed are macrocyclic compounds of formula (I) comprising a 2-carboxy indole ring. Such compounds, and their pharmaceutically acceptable salts, are useful as Mcl-1 (myeloid cell leukemia-1) inhibitors. The compounds may be used in treating a disease o

N-alkyl-cyanopyrazole synthetic method

The invention discloses an N-alkyl-cyanopyrazole synthetic method which comprises the following step of by taking 1-alkyl-1H-pyrazole formaldehyde or a derivative thereof, ammonia water, sodium bromate and acetic acid as raw materials and water as a reaction solvent to obtain N-alkyl-cyanopyrazole . The synthetic method provided by the invention is simple in technology without using extremely toxic substances, convenient in synthesis, high in yield, convenient in purification of an obtained product and beneficial to large-scale industrial production.

2-(1H-INDAZOL-6-YLAMINO)-BENZAMIDE COMPOUNDS AS PROTEIN KINASES INHIBITORS USEFUL FOR THE TREATMENT OF OPHTALMIC DISEASES

Indazole compounds that modulate and/or inhibit the ophthalmic diseases and the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating ophthalmic diseases and cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma,rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.