308110-28-3Relevant articles and documents
PYRIDINYL AND PYRAZINYL-(AZA)INDOLSULFONAMIDES
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Page/Page column 92; 97-98, (2020/01/11)
The present invention relates to pyridinyl and pyrazinyl-(aza)indolsulfonamides having GPR17 modulator activity. The compounds have utility in the treatment of a variety of GPR17-associated disorders.
Structural Optimization of Indole Derivatives Acting at Colchicine Binding Site as Potential Anticancer Agents
Hwang, Dong-Jin,Wang, Jin,Li, Wei,Miller, Duane D.
, p. 993 - 997 (2015/09/22)
A new series of indole analogues based on our earlier lead compound, 2-(1H-indol-5-yl)-4-(3,4,5-trimethoxyphenyl)-1H-imidazo[4,5-c]pyridine (42), was prepared as tubulin inhibitors in an effort to find a molecule with improved cytotoxic potency and metabo
4- And 5-aroylindoles as novel classes of potent antitubulin agents
Liou, Jing-Ping,Wu, Chang-Ying,Hsieh, Hsing-Pang,Chang, Chi-Yen,Chen, Chi-Ming,Kuo, Ching-Chuan,Chang, Jang-Yang
, p. 4548 - 4552 (2008/02/13)
A novel series of 4- and 5-aroylindole derivatives was prepared and evaluated for antitumor activity. Several compounds showed excellent antiproliferative activity as inhibitors of tubulin polymerization. Compounds 13,14,15, and 18, with IC50 v
