31217-00-2

Basic information

• Product Name: 5-Chloro-1,3-dimethyluracil
• Synonyms: 1,3-Dimethyl-5-chlorouracil;5-Chloro-1,3-dimethyluracil;5-Chloro-1,3-diMethylpyriMidine-2,4(1H,3H)-dione
• CAS NO: 31217-00-2
• Molecular Formula: C₆H₇ClN₂O₂
• Molecular Weight: 174.59
• Mol File: 31217-00-2.mol
• Article Data: 13

Chemical Properties

• Melting Point: 140-148 °C(Solv: ethanol (64-17-5); hexane (110-54-3))
• Boiling Point: 224.6±50.0 °C(Predicted)
• Appearance: /
• Density: 1.43±0.1 g/cm3(Predicted)
• PKA: -3.81±0.40(Predicted)
• CAS DataBase Reference: 5-Chloro-1,3-dimethyluracil(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-1,3-dimethyluracil(31217-00-2)
• EPA Substance Registry System: 5-Chloro-1,3-dimethyluracil(31217-00-2)

Safety Data

• Hazardous Substances Data: 31217-00-2(Hazardous Substances Data)

Upstream product

• 874-14-6 1,3-dimethyluracil 
• 64-19-7 acetic acid 
• 937-14-4 3-chloro-benzenecarboperoxoic acid 
• 119255-07-1 5,5'-mercuribis(1,3-dimethyluracil) 

Downstream Products

• 1420467-03-3 5-chloro-1,3-dimethyl-6-(p-chlorophenyl)uracil 
• 1420467-02-2 5-chloro-1,3-dimethyl-6-(p-methoxyphenyl)uracil 
• 1420467-01-1 5-chloro-1,3-dimethyl-6-(p-tolyl)uracil 
• 1381948-78-2 5-chloro-1,3-dimethyl-6-phenyluracil 
• 129056-81-1 5-Carboxymethyl-1,3-dimethyluracil 
• 136738-88-0 1,3-dimethyl-5,6-dihydro-5-(p-methylbenzyl)-5-(2,5-xylyl)uracil 
• 136738-87-9 1,3-dimethyl-5,6-dihydro-5-(2,5-xylyl)uracil 
• 105202-34-4 1,3-dimethyl-5-o-tolylpyrimidine-2,4(1H,3H)-dione 
• 105202-37-7 1,3-dimethyl-6-o-tolylpyrimidine-2,4(1H,3H)-dione 
• 105202-39-9 1,3-dimethyl-6-p-tolylpyrimidine-2,4(1H,3H)-dione 
• 105202-38-8 1,3-dimethyl-6-(3-methylphenyl)uracil 
• 105202-36-6 1,3-dimethyl-5-p-tolylpyrimidine-2,4(1H,3H)-dione 
• 105202-35-5 1,3-dimethyl-5-(m-tolyl)pyrimidine-2,4(1H,3H)-dione 
• 110225-42-8 1,3-dimethyl-5-(2,5-dimethylphenyl)uracil 

Relevant articles and documents

Practical halogenations of nucleosides using tetrabutylammonium peroxydisulfate

Direct halogenation of a wide range of acetylated pyrimidine and purine nucleosides was achieved with high regioselectivity in good yields using tetrabutylammonium peroxydisulfate 1. Treatment of protected nucleosides with HCl/DMF or inorganic salts such as LiCl or NaCl in MeCN/AcOH in the presence of 1 gave the corresponding chlorinated nucleosides and bromination was achieved with N-bromosuccinimide in MeCN in the presence of 1.

Controlled C-5 chlorination and dichlorohydrin formation of uracil ring with HCl/DMF/Oxone system

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Novel process for generating useful electrophiles from common anions using Selectfluor fluorination agent

In the present work, the electrophile equivalents C1+, Br+, SCN+, and NO2+ are generated from their respective sodium, potassium, and in some cases ammonium salts (M+X-) by reaction with Selectfluor electrophilic fluorination agent in acetonitrile solution at room temperature. These generated electrophilic species subsequently react in situ with a variety of aromatic substrates containing one or more substituent groups including H, F, C1, CH3, COOH, C(O)CH3, NO2, and OR′ and NR′R″ where R′ and R″ are H or CH3. The resulting substitution products are, in most cases, isolable as pure compounds in high yield. Variations in the process include the use of other anions, electrophilic fluorination agents, and solvents.