312615-59-1

Basic information

• Product Name: 2-oxo-6-trifluoromethyl-2H-pyran-3-yl-N-benzamide
• Synonyms: 2-oxo-6-trifluoromethyl-2H-pyran-3-yl-N-benzamide
• CAS NO: 312615-59-1
• Molecular Weight: 283.207
• Mol File: 312615-59-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 179 °C(Solv: toluene (108-88-3))
• Boiling Point: 417.6±45.0 °C(Predicted)
• Density: 1.44±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 2-oxo-6-trifluoromethyl-2H-pyran-3-yl-N-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-oxo-6-trifluoromethyl-2H-pyran-3-yl-N-benzamide(312615-59-1)
• EPA Substance Registry System: 2-oxo-6-trifluoromethyl-2H-pyran-3-yl-N-benzamide(312615-59-1)

Safety Data

• Hazardous Substances Data: 312615-59-1(Hazardous Substances Data)

Upstream product

• 495-69-2 Hippuric Acid 
• 59938-06-6 (E)-4-Ethoxy-1,1,1-trifluoro-3-buten-2-one 
• 127223-93-2 (E)-4-(dimethylamino)-1,1,1-trifluorobut-3-en-2-one 
• 1199-01-5 2-phenylazlactone 
• 59938-06-6 4-ethoxy-1,1,1-trifluoro-3-butene-2-one 

Downstream Products

• 748784-98-7 1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-pyridinyl-N-benzamide 
• 733762-50-0 1,2,5,6-tetrahydro-6-hydroxy-1-(2-methoxyethyl)-2-oxo-6-(trifluoromethyl)-3-pyridinyl-N-benzamide 
• 350-98-1 N-(4-(trifluoromethyl)phenyl)benzamide 
• 748785-01-5 N-[(5-trifluoromethyl)biphenyl-2-yl]benzamide 
• 1198018-25-5 2-benzoylamino-6,6,6-trifluoro-5-methoxyhexa-2,4-dienoic acid triethylammonium salt 
• 1305340-18-4 C₁₇H₁₅F₃N₂O₄ 

Relevant articles and documents

TRANSGLUTAMINASE 2 (TG2) INHIBITORS

Described herein are compounds and pharmaceutical compositions containing such compounds which inhibit transglutaminase 2 (TG2). Also described herein are methods for using such TG2 inhibitors, alone or in combination with other compounds, for treating diseases or conditions that would benefit from TG2 inhibition.

A convenient synthesis and chemical properties of 3-acylamino-6- polyfluoroalkyl-2H-pyran-2-ones

A number of 3-acylamino-6-polyfluoroalkyl-2H-pyran-2-ones 3 were synthesized from β-alkoxyvinyl polyfluoroalkyl ketones 1 and N-acylglycines 2 in acetic anhydride in high yield. The reactions of trifluoromethyl- containing 2H-pyran-2-one 3b with O-and N-n