31385-12-3

Basic information

• Product Name: Benzoic acid, 2-[(trifluoroacetyl)amino]-, methyl ester
• CAS NO: 31385-12-3
• Molecular Formula: C10H8F3NO3
• Molecular Weight: 247.174
• Mol File: 31385-12-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-[(trifluoroacetyl)amino]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-[(trifluoroacetyl)amino]-, methyl ester(31385-12-3)
• EPA Substance Registry System: Benzoic acid, 2-[(trifluoroacetyl)amino]-, methyl ester(31385-12-3)

Safety Data

• Hazardous Substances Data: 31385-12-3(Hazardous Substances Data)

Upstream product

• 134-20-3 2-carbomethoxyaniline 
• 76-05-1 trifluoroacetic acid 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 1904-58-1 anthranilic acid hydrazide 
• 152062-96-9 3-amino-2-(trifluoromethyl)quinazolin-4(3H)-one 

Relevant articles and documents

Identification of novel quinazolin-4(3H)-ones as inhibitors of thermolysin, the prototype of the M4 family of proteinases

A combinatorial series of novel quinazolin-4(3H)-ones were synthesised and their structures were established based on spectroscopic data (IR, NMR, EI-MS, and FAB-MS). The compounds were tested for inhibition of the zinc metalloproteinase thermolysin (TLN) utilizing a chemical array-based approach. Some of the compounds were found to inhibit TLN, with IC50 values ranging from 0.0115 μM (compound 3) to 122,637 μM (compound 29). Compound 3 [3-phenyl-2-(trifluoromethyl) quinazolin-4(3H)-one] (IC50 = 0.0115 μM) and compound 35 [3-(isopropylideneamino)-2,2-dimethyl-2,3-dihydroquinazolin-4 (1H)-one] (IC50 = 0.2477 μM) were found to be the most potent inhibitors.

Some halogenated acetyl derivatives and their antitumor activity.

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