31731-23-4

Basic information

• Product Name: 3-(2-NITROETHYL)INDOLE
• Synonyms: 3-(2-NITROETHYL)INDOLE;Nsc63824;3-(2-nitroethyl)-1H-indole
• CAS NO: 31731-23-4
• Molecular Formula: C₁₀H₁₀N₂O₂
• Molecular Weight: 190.1986
• Mol File: 31731-23-4.mol
• Article Data: 30

Chemical Properties

• Boiling Point: 407.5°Cat760mmHg
• Flash Point: 200.2°C
• Appearance: /
• Density: 1.289g/cm³
• Vapor Pressure: 7.53E-07mmHg at 25°C
• Refractive Index: 1.654
• CAS DataBase Reference: 3-(2-NITROETHYL)INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-NITROETHYL)INDOLE(31731-23-4)
• EPA Substance Registry System: 3-(2-NITROETHYL)INDOLE(31731-23-4)

Safety Data

• Hazardous Substances Data: 31731-23-4(Hazardous Substances Data)

Usage

General Description

3-(2-NITROETHYL)INDOLE, also known as 3-Nitro-2-Indoline Ethyl Ether, is a chemical compound with the molecular formula C10H10N2O2. It is a member of the indole family and contains a nitro group and an ethyl group attached to the indole ring. 3-(2-NITROETHYL)INDOLE is known for its potential use in various applications, including in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. However, it is also important to note that 3-(2-NITROETHYL)INDOLE may pose health and environmental hazards, and proper handling and disposal procedures should be followed when working with this chemical.

InChI:InChI=1/C10H10N2O2/c13-12(14)6-5-8-7-11-10-4-2-1-3-9(8)10/h1-4,7,11H,5-6H2

Upstream product

• 120-72-9 indole 
• 3638-64-0 1-nitroethylene 
• 3156-51-2 3-(2-nitroethenyl)-1H-indole 
• 1309601-79-3 C₁₀H₁₀N₂O₃ 
• 87-52-5 3-(Dimethylaminomethyl)indole 
• 2483-57-0 methyl 2-nitroacetate 
• 487-89-8 Indole-3-carboxaldehyde 
• 75-52-5 nitromethane 
• 620598-21-2 (N-triisopropylsilyl-1H-indol-3-yl)-N,N,N-trimethylmethanaminium iodide 
• 687-51-4 H-L-Leu-NH₂ 
• 113747-79-8 butyl 3-(3-indolyl)-2-methyl-2-nitropropionate 
• 626-35-7 nitroacetic acid ethyl ester 
• 3156-51-2 3-[(E)-2-nitroeth-1-enyl]-1H-indole 
• 63971-99-3 ethyl 3-(1H-indol-3-yl)-2-nitropropanoate 

Downstream Products

• 61-54-1 tryptamine 
• 128593-29-3 (+/-)-2-hydroxy-1-phenyl-1,2,3,4-tetrahydro-β-carboline 
• 142696-56-8 (S)-1-phenyl-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole 
• 148261-76-1 (R)-1-phenyl-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole 
• 98664-58-5 (+/-)-2-hydroxy-1-(4-methoxyphenyl)-1,2,3,4-tetrahydro-β-carboline 
• 213841-84-0 N-benzylidene-N-[2-(3-indolyl)ethyl]amine oxide 
• 178326-72-2 (S)-2-hydroxy-1-phenyl-tetrahydro-β-carboline 
• 213841-85-1 N-(4-methoxybenzylidene)-N-[2-(3-indolyl)ethyl]amine oxide 
• 213841-86-2 N-(4-nitrobenzylidene)-N-[2-(3-indolyl)ethyl]amine oxide 
• 98664-54-1 C₁₇H₁₅ClN₂O 
• 213841-85-1 C₁₈H₁₈N₂O₂ 
• 98664-55-2 C₁₇H₁₅BrN₂O 
• 128965-38-8 C₂₂H₂₅N₃O₃S 
• 128965-37-7 C₂₃H₂₅N₃O₅S 

Relevant articles and documents

Synthesis and receptor-affinity profile of N-hydroxytryptamine derivatives for serotonin and tryptamine receptors. A molecular-modeling study.

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2D-2D Nanocomposite of MoS2-Graphitic Carbon Nitride as Multifunctional Catalyst for Sustainable Synthesis of C3-Functionalized Indoles

A nanocomposite of two-dimensional MoS2 supported on graphitic C3N4 nanosheets has been prepared by a facile ultrasonication method followed by demonstrating its ability to catalyze the synthesis of several indole derivatives. The as-prepared nanocomposite catalyst was characterized in detail by using different microscopic and spectroscopic techniques to understand its structure and physicochemical properties. Subsequently, this nanocomposite catalyst was used as a heterogeneous multifunctional catalyst to synthesize several C3-functionalized indoles in the aqueous medium. The employed strategy also provided very good catalyst recyclability and versatility for the synthesis of various precursors of medicinally significant indoles, such as serotonin, melatonin, and various β-carboline alkaloids. In addition, a natural product derivate has been prepared on the gram-scale by using this methodology. Furthermore, high atom economy (100 %) and lower E-factor (0.042) makes this strategy a sustainable approach for the synthesis of C3-functionalized indoles.

New insights into the catalytic reduction of aliphatic nitro compounds with hypophosphites under ultrasonic irradiation

This work describes an efficient process for the reduction of nitro compounds to the corresponding amines with a catalytic amount of Pd/C (0.6 mol%), and a mixture of sodium hypophosphite and hypophosphorous acid as a reducing agent in H2O/2-MeTHF at 60 °C. The reaction was optimized under silent conditions. The conditions for the in situ production of H2 using the mixture NaH2PO2/H3PO2 were studied. The influence of ultrasonic activation was investigated both in terms of efficiency and kinetics. The reaction was shown to be efficient in water, at 70 °C with a quantitative conversion and a maximal yield in only 15 min thanks to the ultrasonic activation. Finally, ultrasound was proved to act as a physical agent of phase transfer.