32051-82-4

Basic information

• Product Name: 5-(1-naphthyl)-2H-tetraazole
• Synonyms: 5-(1-naphthyl)-2H-tetraazole
• CAS NO: 32051-82-4
• Molecular Formula: C₁₁H₈N₄
• Molecular Weight: 196.20802
• Mol File: 32051-82-4.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(1-naphthyl)-2H-tetraazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(1-naphthyl)-2H-tetraazole(32051-82-4)
• EPA Substance Registry System: 5-(1-naphthyl)-2H-tetraazole(32051-82-4)

Safety Data

• Hazardous Substances Data: 32051-82-4(Hazardous Substances Data)

Upstream product

• 86-53-3 1-Cyanonaphthalene 
• 13504-46-6 1-naphtylaldehyde oxime 
• 66-77-3 1-naphthaldehyde 

Downstream Products

• 82004-98-6 1-(2-Methoxy-phenyl)-3-[2-(5-naphthalen-1-yl-tetrazol-2-yl)-acetyl]-urea 
• 91-20-3 naphthalene 
• 24973-91-9 1H-Cyclobutanaphthalene 
• 86-53-3 1-Cyanonaphthalene 
• 82004-97-5 1-<5-(α-naphthyl)tetrazol-2-acetyl>-3-(4-methylphenyl)carbamide 
• 82004-95-3 1-[2-(5-Naphthalen-1-yl-tetrazol-2-yl)-acetyl]-3-o-tolyl-urea 
• 82004-96-4 1-[2-(5-Naphthalen-1-yl-tetrazol-2-yl)-acetyl]-3-m-tolyl-urea 
• 68047-37-0 2-(4-bromophenyl)-5-(naphthalen-1-yl)-1,3,4-oxadiazole 
• 197089-41-1 2-(1-Naphthyl)-5-(4-vinylphenyl)-1,3,4-oxadiazole 
• 1320161-64-5 2-(naphthalen-1-yl)-5-(1-phenyl-1H-1,2,3-triazol-4-yl)-1,3,4-oxadiazole 
• 1320161-75-8 2-(naphthalen-2-yl)-5-(1-phenyl-1H-1,2,3-triazol-4-yl)-1,3,4-oxadiazole 

Relevant articles and documents

Catalytic conversion of 2,4,5-trisubstituted imidazole and 5-substituted 1H-tetrazole derivatives using a new series of half-sandwich (η6-p-cymene)Ruthenium(II) complexes with thiophene-2-carboxylic acid hydrazone ligands

A new series of half-sandwich (η6-p-cymene) ruthenium(II) complexes with thiophene-2-carboxylic acid hydrazide derivatives [Ru(η6-p-cymene)(Cl)(L)] [L = N'-(naphthalen-1-ylmethylene)thiophene-2-carbohydrazide (L1), N'-(anthracen-9-ylmethylene)thiophene-2-carbohydrazide (L2) and N'-(pyren-1-ylmethylene)thiophene-2-carbohydrazide (L3)] were synthesized. The ligand precursors and their Ru(II) complexes (1–3) were structurally characterized by spectral (IR, UV–Vis, NMR and mass spectrometry) and elemental analysis. The molecular structures of the ruthenium(II) complexes 1–3 were determined by single-crystal X-ray diffraction. All complexes were used as catalysts for the one-pot three-component syntheses of 2,4,5-trisubstitued imidazole and 5-substituted 1H-tetrazole derivatives. The catalytic studies optimized parameters as solvent, temperature and catalyst. The catalysts revealed very active for a broad range of aromatic aldehydes presenting either electron attractor or electron donor substituents and, although less active, moderate to high activities were observed for alkyl aldehydes.

Design and synthesis of low molecular weight compounds with complement inhibition activity

An attempt was made to synthesize a series of non-cytotoxic low molecular weight compounds of varying substitutions and functionalities having pharmacophore activity like carbonyl compounds, carboxylic acid and bioisosteres like tetrazole and phenyl acrylic acid. The in vitro assay of these analogues for the inhibition of complement activity revealed significant inhibitory activity for varying substituents and, particularly, for bioisosteres, that is, tetrazole and phenyl acrylic acid derivatives.

Preparation of Tetrazoles from Organic Nitriles and Sodium Azide in Micellar Media

An effective method for the preparation of 5-substituted tetrazoles from the corresponding nitriles in micellar media is described. It was demonstrated that almost quantitative yields of tetrazoles can be obtained if the amount of water-surfactant is optimized. The advantages of the methods presented over many others currently used are the simplicity, facility of isolation of tetrazole products and elimination of using relatively expensive solvents and reagents.