32305-28-5

Basic information

• Product Name: Benzoic acid, 4-chloro-2-[(2-methylphenyl)amino]-
• CAS NO: 32305-28-5
• Molecular Formula: C14H12ClNO2
• Molecular Weight: 261.708
• Mol File: 32305-28-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-chloro-2-[(2-methylphenyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-chloro-2-[(2-methylphenyl)amino]-(32305-28-5)
• EPA Substance Registry System: Benzoic acid, 4-chloro-2-[(2-methylphenyl)amino]-(32305-28-5)

Safety Data

• Hazardous Substances Data: 32305-28-5(Hazardous Substances Data)

Upstream product

• 66909-52-2 2,4-dichlorobenzoic acid potassium salt 
• 95-53-4 o-toluidine 
• 212892-02-9 methyl 4-chloro-2-(((trifluoromethyl)sulfonyl)oxy)benzoate 
• 22717-55-1 methyl 4-chloro-2-hydroxybenzoate 
• 5106-98-9 4-chlorosalicylic acid 
• 77817-51-7 4-Chloro-2-o-tolylamino-benzoic acid methyl ester 

Downstream Products

• 195370-33-3 C₁₅H₁₅ClN₄OS 
• 75412-49-6 4-Chloro-2-o-tolylamino-benzoic acid [1-(4,5-dimethoxy-2-nitro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 75412-43-0 4-Chloro-2-o-tolylamino-benzoic acid [1-(3-nitro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 75412-42-9 4-Chloro-2-o-tolylamino-benzoic acid [1-(2-nitro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 75412-48-5 4-Chloro-2-o-tolylamino-benzoic acid [1-(4-hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide 
• 75412-47-4 4-Chloro-2-o-tolylamino-benzoic acid [1-(4-dimethylamino-phenyl)-meth-(E)-ylidene]-hydrazide 
• 75412-45-2 4-Chloro-2-o-tolylamino-benzoic acid [1-(2-chloro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 75412-46-3 4-Chloro-2-o-tolylamino-benzoic acid [1-(4-chloro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 75412-44-1 4-Chloro-2-o-tolylamino-benzoic acid [1-(4-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide 
• 75412-39-4 4-Chloro-2-o-tolylamino-benzoic acid hydrazide 
• 77817-51-7 4-Chloro-2-o-tolylamino-benzoic acid methyl ester 

Relevant articles and documents

Parallel synthesis of 9-aminoacridines and their evaluation against chloroquine-resistant Plasmodium falciparum

A parallel synthetic strategy to the 9-aminoacridine scaffold of the classical anti-malarial drug quinacrine (2) is presented. The method features a new route to 9-chloroacridines that utilizes triflates of salicylic acid derivatives, which are commercially available in a variety of substitution patterns. The route allows ready variation of the two diversity elements present in this class of molecules: the tricyclic aromatic heterocyclic core, and the disubstituted diamine sidechain. In this study, a library of 175 compounds was designed, although only 93 of the final products had purities acceptable for screening. Impurity was generally due to incomplete removal of 9-acridones (18), a degradation product of the 9-chloroacridine synthetic intermediates. The library was screened against two strains of Plasmodium falciparum, including a model of the drug-resistant parasite, and six novel compounds were found to have IC50 values in the low nanomolar range.