32338-02-6

Basic information

• Product Name: 2-BROMO-4-METHOXY-PHENYLAMINE
• Synonyms: 2-BROMO-4-METHOXY-PHENYLAMINE;2-BROMO-4-METHOXYANILINE;2-Bromo-p-anisidine;2-N,4-N-diethyl-6-ethylsulfanyl-1,3,5-triazine-2,4-diamine;ethyl-[4-(ethylamino)-6-(ethylthio)-s-triazin-2-yl]amine;N2,N4-diethyl-6-ethylsulfanyl-1,3,5-triazine-2,4-diamine;2-Bromo-4-methoxyaniline 95%;4-Amino-3-bromoanisole, 2-Bromo-p-anisidine
• CAS NO: 32338-02-6
• Molecular Formula: C₇H₈BrNO
• Molecular Weight: 202.04852
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds
• Mol File: 32338-02-6.mol
• Article Data: 39

Chemical Properties

• Melting Point: 64 °C
• Boiling Point: 265.1 °C at 760 mmHg
• Flash Point: 114.1 °C
• Appearance: /
• Density: 1.531 g/cm³
• Vapor Pressure: 0.00935mmHg at 25°C
• Refractive Index: 1.595
• Storage Temp.: 2-8°C(protect from light)
• PKA: 3.14±0.10(Predicted)
• CAS DataBase Reference: 2-BROMO-4-METHOXY-PHENYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-4-METHOXY-PHENYLAMINE(32338-02-6)
• EPA Substance Registry System: 2-BROMO-4-METHOXY-PHENYLAMINE(32338-02-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 32338-02-6(Hazardous Substances Data)

Usage

Description

2-BROMO-4-METHOXY-PHENYLAMINE is an organic compound that serves as a reagent and reactant in various chemical reactions, particularly in organometallics and organic synthesis. Its unique structure, featuring a bromo and methoxy group attached to an aniline, makes it a versatile building block for the development of new compounds and materials.

Uses

Used in Organometallic Chemistry:
2-BROMO-4-METHOXY-PHENYLAMINE is used as a reagent in organometallic chemistry for the synthesis of metal complexes and coordination compounds. Its presence in these reactions allows for the formation of stable complexes with specific properties, which can be utilized in various applications, such as catalysis, materials science, and pharmaceuticals.
Used in Organic Synthesis:
In the field of organic synthesis, 2-BROMO-4-METHOXY-PHENYLAMINE is employed as a reactant for the preparation of a wide range of organic compounds. Its functional groups can be selectively modified or used as starting points for the formation of new chemical bonds, enabling the synthesis of complex molecules with potential applications in various industries.
Used in Pharmaceutical Industry:
2-BROMO-4-METHOXY-PHENYLAMINE is used as a building block in the pharmaceutical industry for the development of new drugs and drug candidates. Its unique structure can be incorporated into drug molecules to impart specific biological activities, such as binding to target proteins or enzymes, modulating cellular pathways, or exhibiting therapeutic effects.
Used in Materials Science:
In materials science, 2-BROMO-4-METHOXY-PHENYLAMINE is utilized as a component in the design and synthesis of new materials with tailored properties. Its incorporation into polymers, coatings, or other materials can result in improved performance, such as enhanced stability, increased reactivity, or specific optical, electronic, or mechanical properties.
Overall, 2-BROMO-4-METHOXY-PHENYLAMINE is a valuable compound in the fields of organometallic chemistry, organic synthesis, pharmaceuticals, and materials science, offering a wide range of applications and potential for further research and development.

InChI:InChI=1/C7H8BrNO/c1-10-5-2-3-7(9)6(8)4-5/h2-4H,9H2,1H3

Upstream product

• 98447-30-4 2-bromo-4-methoxy-1-nitrobenzene 
• 104-94-9 4-methoxy-aniline 
• 95970-05-1 2,6-dibromo-4-methoxyaniline 
• 106-49-0 p-toluidine 
• 67-56-1 methanol 
• 577-19-5 2-nitrophenyl bromide 
• 700-36-7 2-bromo-4-fluoronitrobenzene 
• 96-96-8 4-methoxy-2-nitroaniline 
• 16133-49-6 5-methoxy-2-nitroaniline 
• 5470-65-5 3-bromo-4-nitrophenol 
• 591-20-8 3-Bromophenol 
• 522613-61-2 (2-bromo-4-methoxy-phenyl)-carbamic acid tert-butyl ester 

Downstream Products

• 146309-27-5 3-(2-Bromo-4-methoxy-phenylcarbamoyl)-2,5-dihydro-pyrrole-1-carboxylic acid benzyl ester 
• 116707-97-2 N-(2-bromo-4-methoxyphenyl)acrylamide 
• 264909-77-5 N-(2-bromo-4-methoxyanilinomethyl)succinimide 
• 908588-80-7 2-bromo-4-methoxy-N-[(1E)-phenylmethylene]aniline 
• 440123-55-7 N-(2-Bromo-4-Methoxy-phenyl)-4-methoxy-benzamide 
• 1279722-91-6 C₁₃H₁₇NO 
• 1279722-92-7 C₁₄H₁₉NO 
• 1279722-99-4 C₁₃H₁₅N₃O 
• 1279723-00-0 C₁₄H₁₇N₃O 
• 13070-45-6 6-Methoxy-1,2,3,4-tetrahydrocarbazole 
• 1279722-88-1 4-methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2yl)benzenamine 
• 1335242-69-7 C₂₂H₁₇ClN₂O 
• 1335242-98-2 C₁₅H₁₄N₂O 
• 18992-85-3 3-methoxycarbazole 

Relevant articles and documents

An easy and efficient access to 2-bromo-4-methoxyaniline

2-Bromo-4-methoxyaniline was obtained by treatment of 2,6-dibromo-4-methoxyaniline with n-butyllithium.

Selective Thiocyanation and Aromatic Amination to Achieve Organized Annulation of Enaminone with Thiocyanate

A tandem insertion of thiocyanate to enamine was performed for the regioselective synthesis of multisubstituted benzoimidazo[2,1-b]thiazoles. This method was shown to be effective in addressing the issue of isomerization encountered in common strategies. With a change made to the leading group on the aniline fragment of enamine, the reaction achieved different transformations, thus enabling multisubstituted benzo[4,5]imidazo[2,1-b]thiazoles and thiazoles in satisfactory yields.

COMPOUNDS AND METHODS FOR TREATMENT OF HEDGEHOG PATHWAY ASSOCIATED CONDITIONS

Provided herein is novel compounds of formula (I), (II), (III), (IV), and (V) as described in the specification, and pharmaceutically acceptable salts, solvates, and prodrugs and compositions thereof, and methods of measuring hedgehog pathway activation in tumor cells, examining tumor cell proliferation, differentiation and apoptosis and using the compounds and pharmaceutical compositions disclosed for treatment of diseases and disorders associated with the hedgehog signaling pathway.