32418-03-4

Basic information

• Product Name: ETHYL 5-ETHOXY-2-PHENYLOXAZOLE-4-CARBOXYLATE
• Synonyms: ETHYL 5-ETHOXY-2-PHENYLOXAZOLE-4-CARBOXYLATE
• CAS NO: 32418-03-4
• Molecular Formula: C₁₄H₁₅NO₄
• Molecular Weight: 0
• Mol File: 32418-03-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ETHYL 5-ETHOXY-2-PHENYLOXAZOLE-4-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 5-ETHOXY-2-PHENYLOXAZOLE-4-CARBOXYLATE(32418-03-4)
• EPA Substance Registry System: ETHYL 5-ETHOXY-2-PHENYLOXAZOLE-4-CARBOXYLATE(32418-03-4)

Safety Data

• Hazardous Substances Data: 32418-03-4(Hazardous Substances Data)

Upstream product

• 96-86-6 diethyl benzamidomalonate 
• 32417-96-2 3-phenyl-1-phthalimido-aziridine-2,2-dicarboxylic acid diethyl ester 
• 119072-55-8 tert-butylisonitrile 
• 81918-05-0 2-Benzoylimino-malonic acid diethyl ester 
• 121-45-9 phosphorous acid trimethyl ester 
• 6829-40-9 aminomalonic acid diethyl ester 
• 98-88-4 benzoyl chloride 
• 81918-02-7 2-Benzoylamino-2-brommalonsaeure-diethylester 
• 685-87-0 Diethyl 2-bromomalonate 
• 100-46-9 benzylamine 
• 13433-00-6 diethyl aminomalonate hydrochloride 

Downstream Products

• 54644-12-1 5-ethoxy-2-phenyloxazole-4-carboxylic acid 
• 890664-46-7 ethyl 5-(4-methylpiperazin-1-yl)-2-phenyloxazole-4-carboxylate 

Relevant articles and documents

Effective C5-Arylation of Peptide-Integrated Oxazoles: Almazole D

An efficient functionalization approach of oxazoles by using Pd-catalyzed cross-coupling reactions is reported. Oxazolone formation and subsequent sulfamoylation in situ are facilitated by employing N,N-diethylsulfamoyl imidazolium triflate. Cross-couplings provide both oxazole-arenes and oxazole-heteroarenes and were compatible with sensitive and epimerization-prone substrates, as exemplified by the total synthesis of the natural product almazole D. (Figure presented.).

Structure-activity relationships of heteroaromatic esters as human rhinovirus 3C protease inhibitors

Human rhinovirus 3C protease (HRV 3Cpro) is known to be a promising target for development of therapeutic agents against the common cold because of the importance of the protease in viral replication as well as its expression in a large number of serotypes. To explore non-peptidic inhibitors of HRV 3Cpro, a series of novel heteroaromatic esters was synthesized and evaluated for inhibitory activity against HRV 3Cpro, to determine the structure-activity relationships. The most potent inhibitor, 7, with a 5-bromopyridinyl group, had an IC50 value of 80 nM. In addition, the binding mode of a novel analog, 19, with the 4-hydroxyquinolinone moiety, was explored by molecular docking, suggesting a new interaction in the S1 pocket.

Cycloadditions of Isocyanides to Azomethine Ylides. Synthesis and Properties of 1-Phthalimidoazetidines

Reactions of isocyanides with 1-phthalimidoaziridines 1,5, and 11 gave 1-phthalimidoazetidines by cycloaddition to the azomethine ylides that are in equilibrium with the aziridines. (tert-Butylimino)azetidines and (tert-octylimino)azetidines rearranged into open-chain azadienes.Reactions of hydrazine hydrate with 1-phthalimidoazetidines did not give the corresponding N-aminoazetidines, but rather their decomposition products, nitrogen and enamino esters.