32445-87-7

Basic information

• Product Name: 2-Methyl-2-(4-trifluoroMethyl-phenyl)-propionitrile
• Synonyms: 2-Methyl-2-(4-trifluoroMethyl-phenyl)-propionitrile;2-METHYL-2-(4-(TRIFLUOROMETHYL)PHENYL)PROPANENITRILE
• CAS NO: 32445-87-7
• Molecular Formula: C₁₁H₁₀F₃N
• Molecular Weight: 213.1990096
• Mol File: 32445-87-7.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Methyl-2-(4-trifluoroMethyl-phenyl)-propionitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-2-(4-trifluoroMethyl-phenyl)-propionitrile(32445-87-7)
• EPA Substance Registry System: 2-Methyl-2-(4-trifluoroMethyl-phenyl)-propionitrile(32445-87-7)

Safety Data

• Hazardous Substances Data: 32445-87-7(Hazardous Substances Data)

Upstream product

• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 55186-75-9 4-trifluoromethyl-α-methylstyrene 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 851233-80-2 potassium 2-cyano-2-methyl-propanoate 
• 78-82-0 Isobutyronitrile 
• 865-47-4 potassium tert-butylate 
• 2338-75-2 4-(Trifluoromethyl)phenylacetonitrile 
• 74-88-4 methyl iodide 
• 402-44-8 4-Fluorobenzotrifluoride 

Downstream Products

• 1004282-76-1 2-methyl-2-(4-trifluoromethyl-phenyl)-propylamine 
• 32445-90-2 2-(p-Trifluoromethylphenyl)-2-methyl-propan-1-ol 
• 32445-99-1 4-isopropyl-1-(trifluoromethyl)benzene 
• 2252-62-2 2-(4-(trifluoromethyl)phenyl)propan-2-ol 
• 57132-21-5 3-p-trifluoromethylphenyl-2-butanone 
• 64436-58-4 2-methyl-1-[4-(trifluoromethyl)phenyl]propan-1-one 
• 32454-17-4 2-methyl-2-(4-(trifluoromethyl)phenyl)propanal 
• 15996-88-0 2-methyl-2-(4-(trifluoromethyl)phenyl)propanamide 

Relevant articles and documents

DITERPENOID COMPOUNDS THAT ACT ON PROTEIN KINASE C (PKC)

This present disclosure relates to protein kinase C (PKC) modulating compounds, methods of treating a subject with cancer using the compounds, and combination treatments with a second therapeutic agent.

Synthesis of indolines by copper-mediated intramolecular aromatic C-H amination

A Cu(OAc)2-mediated intramolecular aromatic C-H amination proceeds with the aid of a picolinamide-type bidentate coordination group to deliver the corresponding indolines in good yields. The reaction occurs smoothly even under noble-metal-free conditions, and in some cases the use of an MnO2 terminal oxidant renders the process catalytic in Cu. The mild oxidation aptitude of Cu(OAc)2 and/or MnO2 accommodates the formation of electron-rich thiophene-and indole-fused indoline analogues. The Cu-based system can provide an effective approach to various indolines of potent interest in pharmaceutical and medicinal chemistry.

17α-HYDROXYLASE/C17,20-LYASE INHIBITORS

The present invention provides compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, A and n are as defined herein. A deuteriated derivative of the compound of Formula (I) is also provided.