324763-39-5 Usage
Description
Benzene, 4-[(2R)-2-(chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)is a complex organic compound with a unique molecular structure. It is characterized by a benzene ring with various substituents, including a chloromethyl group, a methylbutyl group, and two methoxypropoxy groups. Benzene, 4-[(2R)-2-(chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)is known for its potential applications in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
Benzene, 4-[(2R)-2-(chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)is used as an intermediate in the preparation of orally active renin inhibitor Aliskiren (A536000). Benzene, 4-[(2R)-2-(chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)plays a crucial role in the synthesis of Aliskiren, which is a medication used to treat hypertension by inhibiting the renin-angiotensin-aldosterone system. Its unique structure and properties make it a valuable component in the development of this medication, contributing to its effectiveness and oral bioavailability.
Check Digit Verification of cas no
The CAS Registry Mumber 324763-39-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,4,7,6 and 3 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 324763-39:
(8*3)+(7*2)+(6*4)+(5*7)+(4*6)+(3*3)+(2*3)+(1*9)=145
145 % 10 = 5
So 324763-39-5 is a valid CAS Registry Number.
InChI:InChI=1/C17H27ClO3/c1-13(2)15(12-18)10-14-6-7-16(20-4)17(11-14)21-9-5-8-19-3/h6-7,11,13,15H,5,8-10,12H2,1-4H3/t15-/m0/s1
324763-39-5Relevant articles and documents
A aliskiren or its salt separation and analysis method
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Paragraph 0115; 0121, (2017/08/25)
The invention relates to a separation analysis method using polysaccharide derivative-bonded and coated silica as a stationary phase and an organic solvent as a mobile phase for separation analysis of aliskiren and isomers thereof, effective separation of the aliskiren and isomers thereof can be realized, and the separation analysis method has the important meaning to the product quality control.
AN IMPROVED PROCESS FOR THE PREPARATION OF ALISKIREN
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Page/Page column 3; 4; 6; 7; 10; 11; 14, (2013/12/03)
The present invention relates to an improved process for the preparation of renin inhibitor Aliskiren intermediates of Formula-II and further conversion into Aliskiren and its pharmaceutically acceptable salts.
Method for Producing an Alpha-Chiral Chloromethyl Compound in a Pure Form
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Page/Page column 3-4, (2009/01/20)
The present invention relates to a process for preparing a specific α-chiral chloromethyl compound in pure or enriched form by distillative removal of the compound mentioned from substance mixtures which comprise this compound and higher-boiling impurities. The α-chiral chloromethyl compound in question is present in crystalline form at room temperature and is a central intermediate for the preparation of a class of medicaments.