33008-36-5

Basic information

• Product Name: α-phenyl-N-(2,6-dimethylphenyl)nitrone
• Synonyms: α-phenyl-N-(2,6-dimethylphenyl)nitrone
• CAS NO: 33008-36-5
• Molecular Weight: 225.29
• Mol File: 33008-36-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: α-phenyl-N-(2,6-dimethylphenyl)nitrone(CAS DataBase Reference)
• NIST Chemistry Reference: α-phenyl-N-(2,6-dimethylphenyl)nitrone(33008-36-5)
• EPA Substance Registry System: α-phenyl-N-(2,6-dimethylphenyl)nitrone(33008-36-5)

Safety Data

• Hazardous Substances Data: 33008-36-5(Hazardous Substances Data)

Upstream product

• 97369-36-3 1,2,3,5-Tetrahydro-7-methyl-2-phenyl-3-phenylsulfonyl-4H-1-benzazepin-4-on 
• 81-20-9 2,6-dimethylnitrobenzene 
• 19064-77-8 C-phenyl-N-p-tolyl-nitrone 
• 3096-63-7 N-(2,6-dimethylphenyl)hydroxylamine 
• 100-52-7 benzaldehyde 

Downstream Products

• 18109-39-2 N-(2,6-diimethylphenyl)benzamide 
• 81724-84-7 N,N-dibenzoyl(2,6-dimethylphenyl)amine 

Relevant articles and documents

An asymmetric pericyclic cascade approach to 3-alkyl-3-aryloxindoles: Generality, applications and mechanistic investigations

The reaction of L-serine derived N-arylnitrones with alkylarylketenes generates asymmetric 3-alkyl-3-aryloxindoles in good to excellent yields (up to 93%) and excellent enantioselectivity (up to 98% ee) via a pericyclic cascade process. The optimization, scope and applications of this transformation are reported, alongside further synthetic and computational investigations. The preparation of the enantiomer of a Roche anti-cancer agent (RO4999200) 1 (96% ee) in three steps demonstrates the potential utility of this methodology.