33046-48-9

Basic information

• Product Name: α-(4-Nitrophenylthio)acetophenone
• Synonyms: α-(4-Nitrophenylthio)acetophenone;α-[(4-Nitrophenyl)thio]acetophenone;2-(4-NITROPHENYLTHIO)ACETOPHENONE
• CAS NO: 33046-48-9
• Molecular Formula: C₁₄H₁₁NO₃S
• Molecular Weight: 273.30704
• Mol File: 33046-48-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 139 °C(Solv: acetone (67-64-1); water (7732-18-5))
• Boiling Point: 449.8°Cat760mmHg
• Flash Point: 225.8°C
• Appearance: /
• Density: 1.32g/cm³
• Vapor Pressure: 2.79E-08mmHg at 25°C
• Refractive Index: 1.647
• CAS DataBase Reference: α-(4-Nitrophenylthio)acetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: α-(4-Nitrophenylthio)acetophenone(33046-48-9)
• EPA Substance Registry System: α-(4-Nitrophenylthio)acetophenone(33046-48-9)

Safety Data

• Hazardous Substances Data: 33046-48-9(Hazardous Substances Data)

Usage

General Description

α-(4-Nitrophenylthio)acetophenone is a chemical compound that belongs to the class of acetophenones and contains a nitrophenylthio group attached to the alpha carbon. It is known for its yellow crystalline properties and is commonly used in research laboratories as a starting material for the synthesis of various organic compounds. The presence of the nitro group confers unique chemical properties to the compound, making it useful in the preparation of pharmaceuticals, dyes, and other specialty chemicals. Additionally, α-(4-Nitrophenylthio)acetophenone is reported to exhibit antibacterial and antifungal activities, further expanding its potential applications in the field of medicine and biotechnology.

InChI:InChI=1/C14H11NO3S/c16-14(11-4-2-1-3-5-11)10-19-13-8-6-12(7-9-13)15(17)18/h1-9H,10H2

Upstream product

• 532-27-4 1-chloroacetophenone 
• 824-78-2 4-nitrophenol sodium salt 
• 13113-79-6 sodium 4-nitrobenzenethiolate 
• 937-32-6 4-nitrobenzenesulfenyl chloride 
• 98-86-2 acetophenone 
• 100-32-3 di(p-nitrophenyl) disulfide 
• 70-11-1 α-bromoacetophenone 
• 1849-36-1 para-nitrobenzenethiol 
• 20718-17-6 2-(dimethyl(oxo)-λ⁶-sulfaneylidene)-1-phenylethan-1-one 
• 98-88-4 benzoyl chloride 
• 16717-64-9 1-azidostyrene 
• 536-74-3 phenylacetylene 

Downstream Products

• 111441-02-2 1-[α-(4-nitro-phenylsulfanyl)-phenacyl]-pyridinium; iodide 
• 332347-28-1 1-chloro-(E)-2-(p-nitrophenylthio)-1-phenylethylene 
• 41024-48-0 2-((4-nitrophenyl)sulfonyl)-1-phenylethan-1-one 
• 99036-59-6 ω-Phenylmercapto-ω-(4-nitro-phenylmercapto)-acetophenon 
• 24257-90-7 phenyl-glyoxal-bis-(4-nitro-phenylhydrazone) 
• 31599-06-1 (E)-1-((2-chloro-2-phenylvinyl)sulfonyl)-4-nitrobenzene 
• 19822-15-2 Benzoyl-(4-nitro-phenylsulfonyl)-diazomethan 
• 19822-16-3 Benzoyl-(4-nitro-phenylsulfonyl)-(triphenylphosphoranyliden-hydrazono)-methan 
• 1248588-14-8 3-ethoxy-2-[(4-nitrophenyl)sulfanyl]-1-phenylprop-2-en-1-one 

Relevant articles and documents

An aryl thiol-vinyl azide coupling reaction and a thiol-vinyl azide coupling/cyclization cascade: efficient synthesis of β-ketosulfides and arene-fused 5-methylene-2-pyrrolidinone derivatives

The addition reaction of thiol to vinyl azide has been extensively studied. Variously substituted aryl thiols are all viable for this coupling process. The scope of the other partner is successfully expanded from α-aryl vinyl azide to α-alkyl vinyl azide.

Regioselective synthesis of 5-(arylsulfanyl)- and 5-(benzylsulfanyl)-6- phenylsalicylates by one-pot cyclizations of 1,3-bis(silyloxy)buta-1,3-dienes with 2-(arylsulfanyl)- and 5-(benzylsulfanyl)-3-ethoxy-1-phenylprop-2-en-1-ones

5-(Arylsulfanyl)-6-phenylsalicylates were prepared by one-pot cyclizations of 1,3-bis(trimethylsilyloxy) buta-1,3-dienes with 2-(arylsulfanyl)-3-ethoxy-1- phenylprop-2-en-1-ones.

One-pot synthesis of sulfides by reaction of disulfides with alkyl halides in the presence of sodium dithionite

Sodium dithionite-promoted synthesis of unsymmetrical diorganyl sulfides by a reaction of diaryl disulfides with alkyl halides at r.t. has been developed. The advantages offered by this method are operational simplicity, a faster reaction, neutral and mild reaction conditions, and moderate to good yields of products.