33178-86-8

Basic information

• Product Name: ALINIDINE
• Synonyms: ST-567;N-(2,6-DICHLOROPHENYL)-4,5-DIHYDRO-N-2-PROPENYL-1H-IMIDAZOL-2-AMINE;ALINIDINE;2-(N-Allyl-2,6-dichloroanilino)-2-imidazoline;N-allyl-N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine
• CAS NO: 33178-86-8
• Molecular Formula: C₁₂H₁₃Cl₂N₃
• Molecular Weight: 270.16
• Product Categories: API
• Mol File: 33178-86-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 130-131° (Sthle, 1973); mp 127-129° (Sthle, 1980)
• Boiling Point: 360.2 °C at 760 mmHg
• Flash Point: 171.7 °C
• Appearance: /
• Density: 1.3 g/cm³
• Vapor Pressure: 2.25E-05mmHg at 25°C
• Refractive Index: 1.611
• Storage Temp.: 2-8°C
• PKA: 10.42(at 25℃)
• CAS DataBase Reference: ALINIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: ALINIDINE(33178-86-8)
• EPA Substance Registry System: ALINIDINE(33178-86-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26
• Hazardous Substances Data: 33178-86-8(Hazardous Substances Data)

Usage

Description

Alinidine is a compound that possesses the ability to block calcium and potassium channels, which is significant in the context of its applications. It is characterized by its elongation of re-polarisation after an action potential, a property that can be utilized in various industries.

Uses

Used in Pharmaceutical Industry:
Alinidine is used as a channel blocker for its ability to inhibit the flow of calcium and potassium ions through their respective channels. This property makes it a valuable asset in the development of medications targeting conditions related to ion channel dysfunction.
Used in Cardiology:
In the field of cardiology, Alinidine is used as an anti-arrhythmic agent due to its effect on repolarisation. Its ability to elongate re-polarisation after an action potential can help regulate heart rhythm and prevent abnormal electrical activity in the heart.
Used in Neurology:
Alinidine can also be utilized in neurology as a therapeutic agent for conditions involving potassium channel dysfunction. Its blocking effect on potassium channels can help stabilize neuronal excitability and potentially alleviate symptoms associated with certain neurological disorders.

InChI:InChI=1/C12H13Cl2N3/c1-2-8-17(12-15-6-7-16-12)11-9(13)4-3-5-10(11)14/h2-5H,1,6-8H2,(H,15,16)

Upstream product

• 107-11-9 1-amino-2-propene 
• 4205-90-7 Clonidine 
• 106-95-6 allyl bromide 

Downstream Products

• 78583-44-5 1-methyl-2-[N-allyl-N-(2,6-dichloro-phenyl)-amino]-2-imidazoline 

Relevant articles and documents

Synthesis method of alinidine medical intermediate 2-(N-allyl-N-2,6-dichlorophenyl)amino-imidazoline

A synthesis method of an alinidine medical intermediate 2-(N-allyl-N-2,6-dichlorophenyl)amino-imidazoline includes the following steps of adding 0.13 mol of 2-(N-2,6-dichlorophenyl)amino-imidazoline, 110 ml of nitromethane and 0.11 mol of sodium sulfite to a reaction vessel provided with a stirrer, a reflux condenser and a dropping funnel, controlling the stirring speed at 130-160 rpm, slowly adding 0.16-0.19 mol of allyl amine, raising the temperature of the solution to 60-65 DEG C after addition, conducting refluxing for 5-6 h, lowing the temperature of the solution to 10-15 DEG C, conducting filtering, reducing pressure to steam out nitromethane, adding 210 ml of oxalic acid to remaining oily matter, conducting decoloration through a molecular sieve, conducting filtering, regulating the pH of filtrate through a potassium bisulfite regulation solution to 9-10, separating out solid, conducting suction filtration, saline solution washing and cyclohexane washing, conducting dehydration through a dehydrating agent, and conducting recrystallization in propionitrile to obtain crystal 2-(N-allyl-N-2,6-dichlorophenyl)amino-imidazoline.