3336-58-1

Basic information

• Product Name: AMMONIUM TRIFLUOROACETATE
• Synonyms: AMMONIUM TRIFLUORACETATE;AMMONIUM TRIFLUOROACETATE;TRIFLUOROACETIC ACID AMMONIUM SALT;Acetic acid, trifluoro-, ammonium salt;Ammonium trifluoroacetate 98%;Ammoniumtrifluoroacetate98%;Trifluoroacetic acid, ammonium salt,98%;Trifluoroacetic acid, ammonium salt, Ammonium 2,2,2-trifluoroethanoate
• CAS NO: 3336-58-1
• Molecular Formula: C₂HF₃O₂*H₃N
• Molecular Weight: 131.05
• EINECS: 222-072-4
• Mol File: 3336-58-1.mol
• Article Data: 9

Chemical Properties

• Melting Point: 123-125 °C(lit.)
• Boiling Point: 72.2 °C at 760 mmHg
• Flash Point: 49.9 °C
• Appearance: White to off-white/Crystalline Powder or Crystals
• Density: 1.3887 (estimate)
• Solubility: H2O: 0.1 g/mL at 25 °C, clear, colorless
• Water Solubility: Soluble in Water.
• Sensitive: Hygroscopic
• CAS DataBase Reference: AMMONIUM TRIFLUOROACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: AMMONIUM TRIFLUOROACETATE(3336-58-1)
• EPA Substance Registry System: AMMONIUM TRIFLUOROACETATE(3336-58-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• F: 3-10
• Hazardous Substances Data: 3336-58-1(Hazardous Substances Data)

Usage

Description

Ammonium trifluoroacetate is a chemical compound with the formula C2H5F3NO2. It is a white crystalline solid that is soluble in water and is commonly used as a reagent in various chemical reactions and processes.

Uses

Used in Chemical Synthesis:
Ammonium trifluoroacetate is used as a reagent in the synthesis of hexafluoro-2-aminopentan-4-one ligand, which is an important intermediate in the production of various pharmaceuticals and agrochemicals.
Used in Analytical Chemistry:
Ammonium trifluoroacetate is used as an additive in liquid chromatography/mass spectrometry systems for tuning and calibrating the instruments, ensuring accurate and reliable results.
Used in Chiral Separations:
Ammonium trifluoroacetate is used as an eluent in chiral separations, specifically for the elution of chiral acids and bases from derivatized polysaccharide stationary phases. This application is particularly useful in the pharmaceutical industry for the separation and analysis of enantiomers, which are molecules that are mirror images of each other but have different biological activities.

InChI:InChI=1/C2HF3O2/c3-2(4,5)1(6)7/h(H,6,7)

Upstream product

• 253127-02-5 9-{(3aR,4R,6S, 6aR)-6-[5-(tert-butyl)-1,3,4-oxadiazol-2-yl]-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl}-N-(4-chloro-2-fluorophenyl)-9H-purin-6-amine 
• 144864-93-7 1-phenyl-4,4,4-trifluorobutane-1,3-dione 
• 144864-94-8 5,5,5-trifluoro-4-hydroxy-pent-3-en-2-one 
• 404-24-0 2,2,2-trifluoro-N-phenylacetamide 

Downstream Products

• 920-66-1 1,1,1,3',3',3'-hexafluoro-propanol 
• 459216-87-6 5-(2-amino-1-hydroxy-2-m-tolyl-ethyl)-1-cyclopentyl-3-methyl-1,3-dihydro-benzoimidazol-2-one hydrochloride 
• 107996-59-8 3-Hydroxymethyl-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 127933-63-5 (diisopropoxyphosphoryl)formic acid 4-nitrophenylhydrazide 
• 53267-69-9 N-Trifluoracetyl-2,5-cyclohexadien-1-alanin-methylamid 

Relevant articles and documents

POLYMORPH

(2S,3S,4R,5R)-2-(5-tert-butyl-[1,3,4]-oxadiazol-2-yl)-5-[6-(4-chloro-2-fluorophenylamino)-purin-9-yl]-tetrahydrofuran-3,4-diol in polymorphic form III.

METHOD FOR TREATING FUNGAL INFECTIONS

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Synergistic combination comprising cryptophycin derivatives and microtubule synergizing agents

A composition for providing a synergistic treatment for cancer comprising a compound selected from the group consisting of Compound I, Compound II, Compound III, Compound IV and Compound V and one or more microtubule synergizing agents is disclosed. Also, a method of treating cancer using a therapeutically effective amount of a compound selected from the group consisting of Compound I, Compound II, Compound III, Compound IV and Compound V and one or more microtubule synergizing agents or radiation therapy is also disclosed.