3360-45-0Relevant articles and documents
Water bridges are essential to neonicotinoids: Insights from synthesis, bioassay and molecular modelling studies
Zhu, Chengchun,Li, Guanglong,Xiao, Keya,Shao, Xusheng,Cheng, Jiagao,Li, Zhong
supporting information, p. 255 - 258 (2018/05/23)
Water-bridged H-bonds have been observed in many cases of ligand-receptor recognitions. To explore the roles of water bridges in the binding of neonicotinoids with receptors, twenty-four neonicotinoid compounds with nine fragments, including 1H-1,2,3-tria
Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10
Ruiz, Francesc X.,Cousido-Siah, Alexandra,Porté, Sergio,Domínguez, Marta,Crespo, Isidro,Rechlin, Chris,Mitschler, André,De Lera, ángel R.,Martín, María Jesús,De La Fuente, Jesús ángel,Klebe, Gerhard,Parés, Xavier,Farrés, Jaume,Podjarny, Alberto
, p. 1989 - 2003 (2015/12/23)
The human enzymes aldose reductase (AR) and AKR1B10 have been thoroughly explored in terms of their roles in diabetes, inflammatory disorders, and cancer. In this study we identified two new lead compounds, 2-(3-(4-chloro-3-nitrobenzyl)-2,4-dioxo-3,4-dihy
A new efficient synthetic method for 3-iodothyronamine and its potent hypothermic efficacy
Kim, Joong-Gon,Song, Young-Kyu,Jeon, Su-Yeon,Lim, Ye-Ji,Ju, Hyunwoo,Choi, Inho,Chung, Chan-Moon
scheme or table, p. 2205 - 2208 (2012/04/04)
We developed a new efficient synthetic method for a 3-iodothyronamine (T1AM) that has advantages of less synthetic steps and much higher overall yield compared to those in the conventional method. Our animal study showed that T1AM synthesized by the method exerted a potent hypothermic effect in non-hibernator mice.