3362-33-2

Basic information

• Product Name: {[(diphenylmethylidene)amino]oxy}(phenyl)methanone
• Synonyms: methanone, [[(diphenylmethylene)amino]oxy]phenyl-
• CAS NO: 3362-33-2
• Molecular Formula: C₂₀H₁₅NO₂
• Molecular Weight: 301.3386
• Mol File: 3362-33-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 442°C at 760 mmHg
• Flash Point: 184°C
• Density: 1.08g/cm³
• Vapor Pressure: 5.18E-08mmHg at 25°C
• Refractive Index: 1.58
• CAS DataBase Reference: {[(diphenylmethylidene)amino]oxy}(phenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: {[(diphenylmethylidene)amino]oxy}(phenyl)methanone(3362-33-2)
• EPA Substance Registry System: {[(diphenylmethylidene)amino]oxy}(phenyl)methanone(3362-33-2)

Safety Data

• Hazardous Substances Data: 3362-33-2(Hazardous Substances Data)

Usage

Description

[(diphenylmethylidene)amino]oxy(phenyl)methanone, commonly known as benzophenone imine, is an organic compound characterized by its molecular formula C19H13NO2. This white to off-white solid is insoluble in water but readily soluble in organic solvents. Benzophenone imine is recognized for its utility in various chemical applications, including organic synthesis, photopolymer production, and pharmaceutical and agrochemical synthesis.

Uses

Used in Organic Synthesis:
Benzophenone imine is utilized as a reagent in organic synthesis, particularly for the formation of carbon-carbon bonds. Its ability to facilitate these bond formations makes it a valuable component in the creation of complex organic molecules.
Used in Photopolymer Production:
As a photoinitiator, benzophenone imine plays a crucial role in the production of photopolymers. It aids in the process by initiating the polymerization reaction when exposed to light, which is essential for the development of various polymer products.
Used in Pharmaceutical and Agrochemical Synthesis:
Benzophenone imine also serves as a synthetic intermediate in the production of pharmaceuticals and agrochemicals. Its unique chemical properties allow it to be a key component in the synthesis of various drugs and agricultural chemicals, contributing to the development of new and improved products in these industries.
Safety Precautions:
It is important to handle benzophenone imine with care, as it may pose health risks if ingested or inhaled. Additionally, it can cause skin and eye irritation, necessitating proper safety measures during its use and storage.

Upstream product

• 574-66-3 Benzophenone oxime 
• 65-85-0 benzoic acid 
• 1485-71-8 benzophenone oxime 
• 119-61-9 benzophenone 
• 98-88-4 benzoyl chloride 

Downstream Products

• 133469-21-3 N-benzhydryl-1-phenylethan-1-amine 
• 70591-20-7 N-(diphenylmethylene)aminoacetonitrile 
• 67174-42-9 N-(1-ethoxyethyl)-1,1-diphenylmethanimine 
• 83196-02-5 2-<(Diphenylmethylidene)amino>cyclohexanone 
• 7699-79-8 benzhydrylidene-benzyl-amine 
• 64999-34-4 1,1-diphenyl-N-(1-phenylethyl)methanimine 
• 522653-45-8 diphenylketimine glycine dimethyl amide 
• 59320-63-7 1,1-diphenyl-N-[(1R)-1-phenylethyl]methanimine 
• 64954-01-4 benzophenone-((S)-1-phenyl-ethylimine) 
• 1439895-21-2 C₂₅H₂₅N 
• 1439895-20-1 C₂₁H₂₅N 
• 1392400-86-0 C₂₂H₁₇BrN₂ 
• 81471-20-7 3-bromo-1-methyl-1H-indole 
• 119-61-9 benzophenone 

Relevant articles and documents

Direct C(sp3)-N Radical Coupling: Photocatalytic C-H Functionalization by Unconventional Intermolecular Hydrogen Atom Transfer to Aryl Radical

An unconventional approach for intermolecular direct C(sp3)-N radical coupling has been developed by photocatalytic C(sp3)-H activation of simple alkyl substrates using O-benzoyl oximes. The selective photocatalytic energy-transfer-driven homolysis followed by decarboxylation generates the persistent iminyl radical and aryl radical, which would undergo an unprecedented intermolecular hydrogen atom abstraction from the alkyl substrate to provide the key C(sp3) radical. Selective radical-radical C-N cross-coupling furnishes imines which are valuable amine building blocks.

A convenient practical synthesis of alkyl and aryl oxime esters

A facile access to the synthesis of alkyl and aryl oxime esters of ketoximes and aldoximes in high yields (90-97%) is reported. The reactions were performed using N-[3-(methylamino)propyl]-N′-ethylcarbodiimide hydrochloride (EDCI) reagent in the presence of 4-(dimethylamino)pyridine (DMAP) as a catalyst at room temperature. The isolation and purification of products is very simple and in cases where product is solid, column chromatography is avoided. Georg Thieme Verlag Stuttgart New York.

(E)-Phenyl- and -heteroaryl-substituted O-benzoyl-(or acyl)oximes as lipoprotein-associated phospholipase A2 inhibitors

A series of (E)-phenyl- and -heteroaryl-substituted O-benzoyl- (or acyl)oximes 3a-n were synthesized for evaluating their human lipoprotein-associated phospholiphase A2 (Lp-PLA2) inhibitory activities. The less lipophilic derivatives 3a-c showed the most potent in vitro inhibitory activity on human Lp-PLA2.