339-41-3Relevant articles and documents
Nitrosoarenes as Nitrogen Source for Generation of Sulfonamides with the Insertion of Sulfur Dioxide under Metal-Free Conditions?
Wang, Xuefeng,Lin, Yanmei,Liu, Jin-Biao,He, Fu-Sheng,Kuang, Yunyan,Wu, Jie
supporting information, p. 1098 - 1102 (2020/07/06)
A metal-free reaction of nitrosoarenes, aryldiazonium tetrafluoroborates, and sulfur dioxide under mild conditions is developed, giving rise to sulfonamides in moderate to good yields. This transformation proceeds efficiently at room temperature in the presence of cyclohexa-1,4-diene with a broad reaction scope. Good functional group compatibility is observed, including cyano, halo, and ester. A plausible mechanism involving a radical process with the insertion of sulfur dioxide is proposed, and cyclohexa-1,4-diene serves as the reductant during the transformation.
Identification of N -phenyl-2-(N -phenylphenylsulfonamido)acetamides as new RORγ inverse agonists: Virtual screening, structure-based optimization, and biological evaluation
Song, Yu,Xue, Xiaoqian,Wu, Xishan,Wang, Rui,Xing, Yanli,Yan, Weiqun,Zhou, Yulai,Qian, Chao-Nan,Zhang, Yan,Xu, Yong
, p. 13 - 26 (2016/04/19)
Retinoic acid receptor-related orphan receptors (RORs) are ligand-dependent transcriptional factors and members of the nuclear receptor superfamily. RORs regulate inflammation, metabolic disorders and circadian rhythm. RORγ is a promising therapeutic drug
N-Glycine-sulfonamides as potent dual orexin 1/orexin 2 receptor antagonists
Aissaoui, Hamed,Koberstein, Ralf,Zumbrunn, Cornelia,Gatfield, John,Brisbare-Roch, Catherine,Jenck, Francois,Treiber, Alexander,Boss, Christoph
scheme or table, p. 5729 - 5733 (2009/06/30)
A series of dual OX1R/OX2R orexin antagonists was prepared based on a N-glycine-sulfonamide core. SAR studies of a screening hit led to compounds with low nanomolar affinity for both receptors and good oral bioavailability. One of these compounds, 47, has demonstrated in vivo activity in rats following oral administration.
