339274-36-1

Basic information

• Product Name: S-tert-butyl cyclohexylcarbamoylthioacetate
• Synonyms: S-tert-butyl cyclohexylcarbamoylthioacetate
• CAS NO: 339274-36-1
• Molecular Weight: 257.397
• Mol File: 339274-36-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: S-tert-butyl cyclohexylcarbamoylthioacetate(CAS DataBase Reference)
• NIST Chemistry Reference: S-tert-butyl cyclohexylcarbamoylthioacetate(339274-36-1)
• EPA Substance Registry System: S-tert-butyl cyclohexylcarbamoylthioacetate(339274-36-1)

Safety Data

• Hazardous Substances Data: 339274-36-1(Hazardous Substances Data)

Upstream product

• 15925-47-0 S-tert-butyl acetothioacetate 
• 3173-53-3 Cyclohexyl isocyanate 

Downstream Products

• 62970-56-3 N-Cyclohexyl-2-(N'-phenyl-hydrazinocarbonyl)-acetamide 

Relevant articles and documents

Versatile synthesis of malonamic acid derivatives from a β-ketothioester

An efficient synthetic route is described that allows the preparation under mild conditions of several types of malonamic acid derivatives. The S-tert-butyl acetothioacetate monoanion reacted with aryl or alkyl isocyanates to give β-amidothioesters in one step and 73-87% yield, after spontaneous deacetylation of tricarbonyl intermediates. Treatment of these thioesters with several aliphatic or aromatic alcohols and amines at room temperature in THF or DME and in the presence of silver trifluoroacetate provided, respectively, the corresponding malonamic acid esters and malonamides in 80-100% yield.