340-71-6

Basic information

• Product Name: 2-oxo-4-phenyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester
• Synonyms: 2-oxo-4-phenyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester
• CAS NO: 340-71-6
• Molecular Weight: 314.264
• Mol File: 340-71-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-oxo-4-phenyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-oxo-4-phenyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester(340-71-6)
• EPA Substance Registry System: 2-oxo-4-phenyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester(340-71-6)

Safety Data

• Hazardous Substances Data: 340-71-6(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 
• 57-13-6 urea 
• 400-36-2 trifluoroacetylacetic acid 

Relevant articles and documents

Polyphosphate ester-mediated synthesis of dihydropyrimidines. Improved conditions for the Biginelli reaction

Dihydropyrimidines 7 are prepared in high yield by a one-pot condensation of aldehydes, acetoacetates, and ureas using a polyphosphate ester-mediated cyclocondensation reaction. Yields are significantly higher than utilizing classical Biginelli reaction c

One-step solvent-free synthesis of fluoroalkyl-substituted 4-hydroxy-2-oxo(thioxo)hexahydropyrimidines in the presence of 1-butyl-3-methylimidazolium tetrafluoroborate

A convenient procedure has been developed for the synthesis of fluoroalkyl-substituted 6-aryl-4-hydroxy-2-oxo-(thioxo)hexahydropyrimidine derivatives by three-component condensation of fluorinated β-dicarbonyl compounds with aromatic aldehydes and urea or

Revisit to the Biginelli reaction: A novel and recyclable bioglycerol-based sulfonic acid functionalized carbon catalyst for one-pot synthesis of substituted 3,4-dihydropyrimidin-2-(1H)-ones

A simple and efficient synthetic protocol has been developed for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones by using a novel bioglycerol-based sulfonic acid functionalized carbon catalyst, devoid of moisture sensitive metal catalysts and corrosive acidic reagents. The developed method has the advantages of good to excellent yields, short reaction times, operational simplicity, and a recyclable catalyst. The catalyst can be prepared by a simple procedure from inexpensive and readily available glycerol and has been shown to be recoverable and reusable up to four cycles without any loss of activity.

Synthesis, characterization and biological evaluation of some dihydropyrimidinones

An efficient and facile one pot synthesis of 3,4-dihydropyrimidinones (Biginelli compounds) from divergent aldehydes, β-keto esters and urea or thiourea under solvent free conditions was performed using citric acid as catalyst, resulted in promising yield