34064-35-2Relevant articles and documents
Nucleophilic Organic Base DABCO-Mediated Chemospecific Meinwald Rearrangement of Terminal Epoxides into Methyl Ketones
Li, Siqi,Shi, Yi,Li, Pingfan,Xu, Jiaxi
, p. 4443 - 4450 (2019/04/30)
Nucleophilic organic base DABCO (1,4-diazabicyclo[2.2.2]octane)-mediated Meinwald rearrangement of various epoxides was investigated. 2-Aryl-, alkenyl-, and alkynylepoxides generate the corresponding methyl ketones chemospecifically in good to excellent yields. The current DABCO-mediated Meinwald rearrangement of epoxides features readily accessible starting materials, a wide substrate scope, a transition-metal- and acid-free environment, and chemospecificity in the isomerization of epoxides.
Novel Ethanediamone Hepcidine Antagonists
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, (2012/09/05)
The present invention relates to novel hepcidin antagonists of formula (I), pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for treatment of disorders in iron metabolism, such as, in particular, iron deficiency diseases and anaemias, in particular anaemias in connection with chronic inflammatory diseases (ACD: anaemia of chronic disease and AI: anaemia of inflammation).
Oxazolidinones as novel human CCR8 antagonists
Jin, Jian,Wang, Yonghui,Wang, Feng,Kerns, Jeffery K.,Vinader, Victoria M.,Hancock, Ashley P.,Lindon, Matthew J.,Stevenson, Graeme I.,Morrow, Dwight M.,Rao, Parvathi,Nguyen, Cuc,Barrett, Victoria J.,Browning, Chris,Hartmann, Guido,Andrew, David P.,Sarau, Henry M.,Foley, James J.,Jurewicz, Anthony J.,Fornwald, James A.,Harker, Andy J.,Moore, Michael L.,Rivero, Ralph A.,Belmonte, Kristen E.,Connor, Helen E.
, p. 1722 - 1725 (2007/10/03)
High-throughput screening of the corporate compound collection led to the discovery of a novel series of N-substituted-5-aryl-oxazolidinones as potent human CCR8 antagonists. The synthesis, structure-activity relationships, and optimization of the series
