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342638-02-2

342638-02-2

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342638-02-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 342638-02-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,2,6,3 and 8 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 342638-02:
(8*3)+(7*4)+(6*2)+(5*6)+(4*3)+(3*8)+(2*0)+(1*2)=132
132 % 10 = 2
So 342638-02-2 is a valid CAS Registry Number.

342638-02-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-tosyl-5-(trifluoromethyl)isoindoline

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:342638-02-2 SDS

342638-02-2Relevant articles and documents

Design and synthesis of novel 2,3-dihydro-1H-isoindoles with high affinity and selectivity for the dopamine D3 receptor

Austin, Nigel E,Avenell, Kim Y,Boyfield, Izzy,Branch, Clive L,Hadley, Michael S,Jeffrey, Phillip,Johnson, Christopher N,Macdonald, Gregor J,Nash, David J,Riley, Graham J,Smith, Alexander B,Stemp, Geoffrey,Thewlis, Kevin M,Vong, Antonio K.K,Wood, Martyn D

, p. 685 - 688 (2001)

Starting from the tetrahydroisoquinoline SB-2770111, a novel series of 5-substituted-2,3-dihydro-1H-isoindoles has been designed. Subsequent optimisation resulted in identification of 19. which has high affinity for the dopamine D3 receptor (pKi 8.3) and ≥ 100-fold selectivity over other aminergic receptors. In rat studies 19 was brain penetrant with an excellent pharmacokinetic profile (oral bioavailability 77%. t1/2 5.2h).

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