34346-01-5 Usage
Description
Poly(DL-Lactide), also known as Poly(D-lactide) (PDLA), is a bioabsorbable and biodegradable polymer derived from a stereospecific cyclic di-ester of lactic acid. It is widely used in the field of biomaterials for the development of various medical devices and drug delivery systems. PDLA is known for its good biocompatibility, and its in vivo degradation products are metabolized and eliminated from the body without causing harmful or toxic side effects.
Uses
Used in Medical Applications:
Poly(DL-Lactide) is used as a bioabsorbable and degradable material for the development of medical devices such as disposable infusion devices, non-removable surgical sutures, and tissue engineering scaffolds. It is also used in the production of bone fixation and bone repair materials, microcapsules for injection, microspheres, and implant materials.
Used in Drug Delivery Systems:
Poly(DL-Lactide) is employed in the development of controlled release and slow release packaging agents for drug delivery. It can be used as a coating for nanoparticles and can be end-group functionalized or used as a macroinitiator/block precursor for the synthesis of drug delivery systems.
Used in Surgical Aids:
Poly(DL-Lactide) is used as a material for surgical sutures, providing an absorbable option for wound closure and healing.
Used in Tissue Engineering:
Poly(DL-Lactide) is utilized in the fabrication of resorbable polylactide scaffolds, which serve as templates for tissue regeneration and repair.
Check Digit Verification of cas no
The CAS Registry Mumber 34346-01-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,3,4 and 6 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 34346-01:
(7*3)+(6*4)+(5*3)+(4*4)+(3*6)+(2*0)+(1*1)=95
95 % 10 = 5
So 34346-01-5 is a valid CAS Registry Number.
InChI:InChI=1/C3H6O3.C2H4O3/c1-2(4)3(5)6;3-1-2(4)5/h2,4H,1H3,(H,5,6);3H,1H2,(H,4,5)
34346-01-5Relevant articles and documents
Sustained-release preparation
-
, (2008/06/13)
A sustained-release preparation comprising a bioactive substance having an acidic group and a biodegradable polymer having an optionally protected basic group which improves the rate of incorporation of the bioactive substance, suppresses its leakage early after administration, and exhibits constantly suppressed release for an extended period of time.
Method of producing sustained-release preparation
-
, (2008/06/13)
A method of producing a sustained-release preparation which includes permitting a water-soluble polypeptide to permeate into a biodegradable matrix in the aqueous solution. The production method of the present invention makes possible the permeation of a water-soluble polypeptide into a biodegradable matrix without bringing the water-soluble polypeptide into contact with an organic solvent. Hence the water-soluble polypeptide is prepared without affecting the water-soluble polypeptide bioactivity and is thus effective for use as a pharmaceutical.
Prolonged release preparation and polymers thereof
-
, (2008/06/13)
A polymer for a prolonged release preparation which comprises (A) a polylactic acid and (B) a copolymer of glycolic acid and a hydroxycarboxylic acid of general formula STR1 wherein R stands for an alkyl group having 2 to 8 carbons, wherein the weight ratio of (A) and (B) is in the range of 10/90 to 90/10. The drug is released at a constant rate from the preparation over the total release period without a large burst at the initial state. Furthermore, the drug release period of the preparation can be freely controlled by varying the blending ratio of (A) and (B).
