345-92-6Relevant articles and documents
Preparation method 4,4 ' -difluorobenzophenone and intermediate thereof
-
Paragraph 0068; 0073-0074; 0075; 0080-0081; 0082; ..., (2021/09/01)
The invention discloses 4-4' -difluorobenzophenone and a preparation method of an intermediate thereof. The preparation method of 4, 4 '- difluorobenzophenone comprises the following steps: S1: 4 - chlorobenzyl chloride and chlorobenzene react under first catalyst to obtain 4, 4' -dichlorophenylmethane. The first catalyst is Lewis acid and/or a molecular sieve with Lewis acid center. S2: The 4, 4 '-dichlorophenylmethane and oxidant are subjected to an oxidation reaction under the action second catalyst to obtain 4, 4' -dichlorobenzophenone. S3: The 4, 4' -dichlorobenzophenone and the alkali metal fluoride are subjected to a halogenation reaction to obtain the invention. The 4' - difluorobenzophenone and the intermediate thereof disclosed by the invention are high in selectivity, high in yield, low in raw material cost, mild in process condition, high in safety and wide in industrial prospect.
Ruthenium-on-Carbon-Catalyzed Facile Solvent-Free Oxidation of Alcohols: Efficient Progress under Solid-Solid (Liquid)-Gas Conditions
Park, Kwihwan,Jiang, Jing,Yamada, Tsuyoshi,Sajiki, Hironao
, p. 1200 - 1205 (2021/12/29)
A protocol for the ruthenium-on-carbon (Ru/C)-catalyzed solvent-free oxidation of alcohols, which proceeds efficiently under solid-solid (liquid)-gas conditions, was developed. Various primary and secondary alcohols were transformed to corresponding aldehydes and ketones in moderate to excellent isolated yields by simply stirring in the presence of 10% Ru/C under air or oxygen conditions. The solvent-free oxidation reactions proceeded efficiently regardless of the solid or liquid state of the substrates and reagents and could be applied to gram-scale synthesis without loss of the reaction efficiency. Furthermore, the catalytic activity of Ru/C was maintained after five reuse cycles.
4,4 ’ - Difluorobenzophenone and preparation method and application thereof
-
, (2021/11/21)
The 4, 4 ’ difluorobenzophenone and the preparation method thereof comprise: mixing a molecular sieve and hydrogen peroxide and with fluorobenzaldehyde to form a mixed solution, oxidizing fluorobenzaldehyde into p-fluorobenzoic acid, wherein the molecular sieve is a catalyst. Hydrochloric acid and zinc chloride are added to the mixed solution to generate p-fluorobenzoyl chloride under the condition that the molecular sieve is used as a catalyst. Fluorobenzene was added to the mixed solution containing the p-fluorobenzoyl chloride to obtain the 4, 4 ’ - difluorobenzophenone. Thus, the synthetic method has the following advantages: 4, the yield of 4 ’ - difluorobenzophenone is not lower 98%, the purity is not lower than 99.999%, and the purity makes it available for preparation of medical grade polyether ether ketone. Reaction conditions are easy to control, and the risk of explosion is reduced to a certain extent.