34772-98-0

Basic information

• Product Name: (E)-3-DIMETHYLAMINO-1-THIOPHEN-2-YL-PROPENONE
• Synonyms: (E)-3-DIMETHYLAMINO-1-THIOPHEN-2-YL-PROPENONE;3-(diMethylaMino)-1-(thiophen-2-yl)prop-2-en-1-one;1-(2-Thienyl)-3-(dimethylamino)-2-propen-1-one;3-(Dimethylamino)-1-thien-2-ylprop-2-en-1-one
• CAS NO: 34772-98-0
• Molecular Formula: C₉H₁₁NOS
• Molecular Weight: 181.25474
• Mol File: 34772-98-0.mol
• Article Data: 78

Chemical Properties

• Melting Point: 197-198℃ (1,4-dioxane )
• Boiling Point: 265.8 °C at 760 mmHg
• Flash Point: 114.6 °C
• Appearance: /
• Density: 1.126 g/cm³
• Vapor Pressure: 0.00895mmHg at 25°C
• Refractive Index: 1.564
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (E)-3-DIMETHYLAMINO-1-THIOPHEN-2-YL-PROPENONE(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-DIMETHYLAMINO-1-THIOPHEN-2-YL-PROPENONE(34772-98-0)
• EPA Substance Registry System: (E)-3-DIMETHYLAMINO-1-THIOPHEN-2-YL-PROPENONE(34772-98-0)

Safety Data

• Hazardous Substances Data: 34772-98-0(Hazardous Substances Data)

Usage

General Description

(E)-3-DIMETHYLAMINO-1-THIOPHEN-2-YL-PROPENONE is a chemical compound with the molecular formula C9H11NOS. It is an organosulfur compound with a thiophene ring and a propenone moiety. (E)-3-DIMETHYLAMINO-1-THIOPHEN-2-YL-PROPENONE is often used as a building block in the synthesis of various pharmaceuticals and agrochemicals due to its unique structure and reactivity. It has been identified as a key intermediate in the production of certain drugs and is also used as a reagent in organic chemistry reactions. Its chemical structure and properties make it a valuable tool in the development of new compounds and materials.

InChI:InChI=1/C9H11NOS/c1-10(2)6-5-8(11)9-4-3-7-12-9/h3-7H,1-2H3

Upstream product

• 88-15-3 2-Acetylthiophene 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 893739-40-7 1-(2-(thiophen-2-yl)phenyl)ethan-1-one 
• 68-12-2 N,N-dimethyl-formamide 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 

Downstream Products

• 187749-78-6 3-benzamido-6-(2-thienyl)-pyran-2-one 
• 190579-92-1 6-(thiophen-2-yl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile 
• 240806-68-2 1-[1-Phenyl-4-(thiophene-2-carbonyl)-1H-pyrazol-3-yl]-ethanone 
• 337512-14-8 3-oxo-2-(phenylhydrazono)-3-(thiophen-2-yl)propionaldehyde 
• 428441-84-3 [3,5-di(2-thienylcarbonyl)phenyl](2-thienyl)methanone 

Relevant articles and documents

Access to α,α-dihaloacetophenones through anodic C[dbnd]C bond cleavage in enaminones

We have developed a method to synthesize α,α-dihaloketones under electrochemical conditions. In this reaction, the Cl- or Br- is oxidized to Cl2 or Br2 at the anode, which undergoes two-step addition reactions with the N,N-dimethyl enaminone, and finally breaks C[dbnd]C of the N,N-dimethyl enaminone to generate α,α-dihaloketones. The electrosynthesis reaction can be conveniently carried out in an undivided electrolytic cell at room temperature. In addition, various functional groups are compatible with this green protocol which can be applied simultaneously to the gram scale without significantly lower yield.

An expedient synthesis of highly functionalized 1,3-dienes by employing cyclopropenes asC4units

An efficient method has been described to synthesize dicarbonyl functionalized 1,3-dienes by cleaving the CC bond of enaminones with cyclopropenes in the presence of a rhodium catalyst. The acetate-substituted cyclopropenes are judiciously chosen as standardC4units of 1,3-diene precursors. The reactions are believed to undergo a unique cutting and insertion process, involving a CC bond cleavage of the enaminone and insertion of a newC(sp2) source with the formation of two C-C single bonds. A broad range of substrates can be used to synthesize the corresponding 1,3-dienes under very mild reaction conditions, including low catalyst-loading, ambient temperature, and a neutral reaction solvent.

An Atom-Economic Synthesis of Functionalized Pyridazines via Multicomponent Reactions Under Pressure and Ultrasonication

Abstract: A three-component reaction of 1 mol of arylhydrazonals with 2 mol of an active methylene compound is realized under pressure to obtained novel functionalized pyridazines with a 96% atom economy. The reaction of arylhydrazonals with active methyl