34786-24-8

Basic information

• Product Name: 1-(Ethylthio)-3-methylbenzene
• Synonyms: 1-(Ethylthio)-3-methylbenzene;1-Ethylthio-3-methylbenzene
• CAS NO: 34786-24-8
• Molecular Formula: C₉H₁₂S
• Molecular Weight: 152.26
• Mol File: 34786-24-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: -45°C (estimate)
• Boiling Point: 224.76°C (estimate)
• Flash Point: 85.5°C
• Appearance: /
• Density: 0.9947
• Vapor Pressure: 0.175mmHg at 25°C
• Refractive Index: 1.5570
• CAS DataBase Reference: 1-(Ethylthio)-3-methylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(Ethylthio)-3-methylbenzene(34786-24-8)
• EPA Substance Registry System: 1-(Ethylthio)-3-methylbenzene(34786-24-8)

Safety Data

• Hazardous Substances Data: 34786-24-8(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Odor

Strong, sweet

Solubility

Insoluble in water

Uses

a. Flavoring agent in the food industry
b. Fragrance ingredient in the perfume industry
c. Intermediate in the synthesis of pharmaceuticals and agrochemicals
d. Production of dyes, polymers, and other industrial applications

Safety precautions

a. Harmful if swallowed or inhaled
b. May cause skin irritation upon contact
c. Handle with care

InChI:InChI=1/C9H12S/c1-3-10-9-6-4-5-8(2)7-9/h4-7H,3H2,1-2H3

Upstream product

• 108-40-7 toluene-3-thiol 
• 75-03-6 ethyl iodide 
• 118736-37-1 1,1-bis(benzenesulphonyl)-5-(3-methylbenzenethio)pentane 
• 118736-32-6 1,1-bis(benzenesulphonyl)-4-(3-methylbenzenethio)butane 
• 118736-23-5 1,1-bis(benzenesulphonyl)-3-(3-methylbenzenethio)propane 
• 118736-22-4 1-iodo-2-(3-methylbenzenethio)ethane 
• 16798-92-8 (2-chloroethyl)(3-methylphenyl)sulfane 
• 33733-73-2 3-bromo-1-(methylthio)benzene 
• 74-88-4 methyl iodide 
• 4886-77-5 3-methylthioanisole 
• 74-96-4 ethyl bromide 
• 46185-83-5 2-ethoxyquinoline 

Downstream Products

• 121034-20-6 C₉H₁₃NOS 
• 74-85-1 ethene 
• 13865-48-0 3-methylphenyl phenyl sulfide 
• 107100-54-9 (4-ethylsulfanyl-2-methyl-phenyl)-phenyl-diazene 
• 777943-99-4 1-bromo-4-ethanesulfanyl-2-methyl benzene 

Relevant articles and documents

NAPHTHYLACETIC ACIDS

The invention is concerned with the compounds of formula (I) and pharmaceutically acceptable salts and esters thereof, wherein X, Q, and R1-R6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.

Metallation reactions. XXI. Metallation of alkyl (alkylthio) benzenes by superbases versus organolithium compounds

The metallation regiochemistry of alkyl(alkylthio)benzenes with butyllithium or with the superbasic mixture of butyllithium with potassium tert-butoxide is described. The reaction pattern depends on the substrate and the reagent. Butyllithium monometallates the thiomethylic carbon of methyl (methylthio) benzenes and bimetallates the thiomethylic and the annular carbon ortho to the thioethereal group. With superbases the metallation occurs at the thiomethylic and methylic carbon. Metallation with butyllithium of the higher homologs substitutes exclusively the hydrogen ortho to the thioalkylic group, while the superbases attack also the carbon atom alpha to the thioalkyl substituent.

PREPARATION OF PHENYL ARYL SULFIDES BY REACTION OF BENZYNE WITH ETHYL ARYL SULFIDES

A variety of ethyl aryl sulfides (1) react with benzyne, with evolution of ethylene, to give phenyl aryl sulfides (3) in excellent yields, thus providing a general synthesis of 3 from arenethiols since 1 are quantitatively obtainable from arenethiols and ethyl bromide.