349420-02-6

Basic information

• Product Name: 2-(4-bromophenyl)-N-[3-(trifluoromethyl)phenyl]acetamide
• Synonyms: 2-(4-bromophenyl)-N-[3-(trifluoromethyl)phenyl]acetamide
• CAS NO: 349420-02-6
• Molecular Formula: C₁₅H₁₁BrF₃NO
• Molecular Weight: 358.1531496
• Mol File: 349420-02-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 463.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.537±0.06 g/cm3(Predicted)
• PKA: 13.75±0.70(Predicted)
• CAS DataBase Reference: 2-(4-bromophenyl)-N-[3-(trifluoromethyl)phenyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-bromophenyl)-N-[3-(trifluoromethyl)phenyl]acetamide(349420-02-6)
• EPA Substance Registry System: 2-(4-bromophenyl)-N-[3-(trifluoromethyl)phenyl]acetamide(349420-02-6)

Safety Data

• Hazardous Substances Data: 349420-02-6(Hazardous Substances Data)

Upstream product

• 98-16-8 3-trifluoromethylaniline 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 

Downstream Products

• 908265-81-6 2-[4-(7-pyridin-4-yl-imidazo[1,2-a]pyridin-3-yl)-phenyl]-N-(3-trifluoromethyl-phenyl)-acetamide 
• 908268-92-8 2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-N-(3-trifluoromethyl-phenyl)-acetamide 

Relevant articles and documents

Discovery of a low-systemic-exposure DGAT-1 inhibitor with a picolinoylpyrrolidine-2-carboxylic acid moiety

A series of diacylglycerol O-acyltransferase 1 (DGAT-1) inhibitors with a picolinoylpyrrolidine-2-carboxylic acid moiety were designed and synthesized. Of these compounds, compound 22 exhibited excellent DGAT-1-inhibitory activity (hDGAT-1 enzyme assay, 50% inhibitory concentration [IC50]=3.5±0.9nM) and effectively reduced the intracellular triglyceride contents in 3T3-L1, HepG2 and Caco-2 cells. A preliminary study of the plasma and tissue distributions of compound 22 in mice revealed low plasma exposure and high concentrations in different segments of the intestine and liver, which may facilitate targeting DGAT-1. Furthermore, in an acute lipid challenge test, compound 22 showed a dose-dependent inhibitory effect on high-serum triglycerides in C57/KSJ mice induced by olive oil (1, 3, and 10mg/kg, i.g.).