350800-70-3

Basic information

• Product Name: N-methyl-N-(3-nitro-5-trifluoromethyl-phenyl)-acetamide
• Synonyms: N-methyl-N-(3-nitro-5-trifluoromethyl-phenyl)-acetamide
• CAS NO: 350800-70-3
• Molecular Weight: 262.188
• Mol File: 350800-70-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-methyl-N-(3-nitro-5-trifluoromethyl-phenyl)-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-N-(3-nitro-5-trifluoromethyl-phenyl)-acetamide(350800-70-3)
• EPA Substance Registry System: N-methyl-N-(3-nitro-5-trifluoromethyl-phenyl)-acetamide(350800-70-3)

Safety Data

• Hazardous Substances Data: 350800-70-3(Hazardous Substances Data)

Upstream product

• 402-00-6 acetic acid-(3-nitro-5-trifluoromethyl-anilide) 
• 74-88-4 methyl iodide 

Downstream Products

• 350800-54-3 N-(3-amino-5-trifluoromethylphenyl)-N-methyl-acetamide 

Relevant articles and documents

5-HT6 receptor antagonists: lead optimisation and biological evaluation of N-aryl and N-heteroaryl 4-amino-benzene sulfonamides

RO-04-6790 (6a) has been identified in a random screen for 5-HT6 receptor antagonists. In a medicinal chemistry optimisation program a series of analogs comprising N-heteroaryl- and N-arylbenzenesulfonamides have been synthesised and investigated for their binding affinity. Compounds with a log D profile indicative of brain penetration have been subjected to in vivo testing for reversal of a scopolamine-induced retention deficit in a passive avoidance paradigm.