352457-35-3

Basic information

• Product Name: MOXONIDINE IMPURITY A
• Synonyms: MOXONIDINE IMPURITY A;4,6-Dichloro-N-(imidazolidin-2-ylidene)-2-methylpyrimidin-5-amine
• CAS NO: 352457-35-3
• Molecular Formula: C₈H₉Cl₂N₅
• Molecular Weight: 246.09656
• EINECS: 934-919-1
• Mol File: 352457-35-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: MOXONIDINE IMPURITY A(CAS DataBase Reference)
• NIST Chemistry Reference: MOXONIDINE IMPURITY A(352457-35-3)
• EPA Substance Registry System: MOXONIDINE IMPURITY A(352457-35-3)

Safety Data

• Hazardous Substances Data: 352457-35-3(Hazardous Substances Data)

Usage

Uses

4''-Desmethoxy-4''-chloro Moxonidine is an impurity of moxonidine.

Upstream product

• 75438-54-9 4,6-dichloro-2-methyl-5-(1-acetyl-2-imidazolin-2-yl)-aminopyrimidine 
• 287099-40-5 mono-Moxonidine oxalate 
• 144-62-7 oxalic acid 
• 75438-57-2 moxonidine 
• 67-56-1 methanol 
• 124-41-4 sodium methylate 

Relevant articles and documents

MOXONIDINE ANALOGS, PREPARATION PROCESSES AND USES THEREFOR

The present invention provides derivatives of moxonidine, 1-[l-[(4,6-dichloro-2-methyl-6-5-pyrimidinyl)imino]ethyl]-2-imidazolidinone of formula (V) and l-[l-[(4-chloro-2-methyl-6-methoxy-5-pyrimidinyl)imino]ethyl]-2-imidazolidinone of formula (VI), which can be used for testing the purity or monitoring the production of moxonidine, and process for preparing the derivatives. Also provided is an improved process for preparing 4,6- dichloro-2-methyl-5-(l-acetyl-2-imidazolin-2-yl)-aminopyrimidine (DMAIA) and a method of utilizing the process to produce moxonidine.

Novel purification process of moxonidine

The present invention provides a novel purification process of Moxonidine avoiding nitromethane and using instead class 3 solvents or selected class 2 solvents for preparing highly pure Moxonidine, e.g, the crystalline Moxonidine form I.