354-32-5 Usage
Description
TRIFLUOROACETYL CHLORIDE is a colorless gas that is shipped as a liquid under its own vapor pressure. It is very toxic by inhalation and can cause severe irritation to the skin, eyes, and mucous membranes upon contact. Prolonged exposure to fire or heat may lead to the violent rupture of containers, posing a risk. It is widely used in various industries, including medicine, pesticides, and as an organic intermediate and fine chemical.
Uses
Used in Pharmaceutical Industry:
TRIFLUOROACETYL CHLORIDE is used as a reagent for the synthesis of various pharmaceutical compounds due to its ability to facilitate specific chemical reactions and improve the efficiency of the drug production process.
Used in Pesticide Industry:
TRIFLUOROACETYL CHLORIDE is used as a key intermediate in the production of certain pesticides, contributing to the development of effective and targeted pest control solutions.
Used in Organic Chemistry:
TRIFLUOROACETYL CHLORIDE is used as a versatile building block in organic chemistry, enabling the synthesis of a wide range of organic compounds for various applications.
Used in Fine Chemical Industry:
TRIFLUOROACETYL CHLORIDE is used as a crucial component in the production of fine chemicals, which are essential for various specialized applications, such as fragrances, dyes, and advanced materials.
Air & Water Reactions
Reacts avidly with water and with moisture in the air to give fumes of hydrogen chloride, a water-soluble toxic gas.
Reactivity Profile
TRIFLUOROACETYL CHLORIDE is incompatible with strong oxidizing agents, alcohols, amines, alkalis. Reacts vigorously with amines and alkalis. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Health Hazard
TOXIC; may be fatal if inhaled, ingested or absorbed through skin. Vapors are extremely irritating and corrosive. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control may cause pollution.
Fire Hazard
Some may burn but none ignite readily. Vapors from liquefied gas are initially heavier than air and spread along ground. Some of these materials may react violently with water. Cylinders exposed to fire may vent and release toxic and/or corrosive gas through pressure relief devices. Containers may explode when heated. Ruptured cylinders may rocket.
Flammability and Explosibility
Notclassified
Safety Profile
Corrosive to skin, eyes,
and materials. When heated to
decomposition it emits very toxic fumes of
Fand Cl-. See also FLUORIDES and
CHLORIDES.
Check Digit Verification of cas no
The CAS Registry Mumber 354-32-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,5 and 4 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 354-32:
(5*3)+(4*5)+(3*4)+(2*3)+(1*2)=55
55 % 10 = 5
So 354-32-5 is a valid CAS Registry Number.
354-32-5Relevant articles and documents
PREPARATION OF CF3-COCl : INVESTIGATION OF OPERATING PARAMETERS
Marangoni, L.,Guglielmo, G.,Conte, L.
, p. 572 (1980)
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Saunders,Slocombe,Hardy
, p. 752 (1949)
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Graves,Lustig
, p. 321,323 (1972)
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Henne,Alm,Smook
, p. 1968 (1948)
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Copper-catalyzed three component C[sbnd]S/C[sbnd]N coupling for the synthesis of trifluorothioacetamides
Hu, Bo-Lun,Song, Yi-Kang,Yao, Zengwen,Zhang, Guoqiang,Zhang, Xing-Guo
supporting information, (2020/10/06)
A copper-catalyzed three component C[sbnd]S/C[sbnd]N coupling reaction of imines with sulfur and CFC-113a was developed. The reaction involves amination and C[dbnd]S double bond formation of CFC-113a, leading to biologically important trifluorothioacetamides. The method features efficient construction of trifluorothioacetyl moiety from cheap sulfur and CFC-113a, and safe disposal for environmentally persistent Freon
Preparation method of trifluoroacetic acid
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Paragraph 0025; 0026; 0028; 0029; 0031; 0032; 0034; 0035, (2019/01/16)
The invention discloses a preparation method of trifluoroacetic acid. The preparation method comprises the following steps: (1), vaporizing 1,1,1-trifluoro-2-chloroethane and chlorine gas, then enabling the 1,1,1-trifluoro-2-chloroethane and chlorine gas to enter a fixed bed reactor with a catalyst, and performing a gas phase chlorination reaction to synthesize 1,1,1-trifluoro-2,2-dichloroethane;(2), vaporizing the 1,1,1-trifluoro-2,2-dichloroethane and oxygen, then performing an oxidation reaction under the action of a light source to obtain trifluoroacetyl chloride, condensing the unreacted1,1,1-trifluoro-2,2-dichloroethane, and then enabling the unreacted 1,1,1-trifluoro-2,2-dichloroethane to return to the reactor; (3), hydrolyzing the trifluoroacetyl chloride to obtain the trifluoroacetic acid. The preparation method has the advantages of a simple technology, high yield, few three wastes and the like; in addition, by the preparation method, the reaction conversion rate is high, the selectivity is high, the reaction production is continuous, and the safety and the environment friendliness are achieved.