35504-95-1

Basic information

• Product Name: 3-methyl-4-oxo-4-(p-tolyl)but-2-enoic acid
• CAS NO: 35504-95-1
• Molecular Weight: 204.225
• Mol File: 35504-95-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-methyl-4-oxo-4-(p-tolyl)but-2-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-4-oxo-4-(p-tolyl)but-2-enoic acid(35504-95-1)
• EPA Substance Registry System: 3-methyl-4-oxo-4-(p-tolyl)but-2-enoic acid(35504-95-1)

Safety Data

• Hazardous Substances Data: 35504-95-1(Hazardous Substances Data)

Upstream product

• 616-02-4 citraconic acid anhydride 
• 108-88-3 toluene 
• 7446-70-0 aluminium trichloride 
• 5337-93-9 4'-methylpropiophenone 
• 298-12-4 Glyoxilic acid 

Downstream Products

• 22895-11-0 3-methyl-4-oxo-4-p-tolyl-butyric acid 

Relevant articles and documents

Efficient Multigram-Scale Synthesis of 7-Substituted 3-Methyltetral-1-ones and 6-Fluoromenadione

Herein, we report a safe and economical multigram synthesis of 6-fluoromenadione, an intermediate in the synthesis of novel biologically active agents. The key to this six-step sequence process involves the condensation of the readily available starting 4′-fluoropropiophenone and glyoxylic acid, a bromination-elimination sequence from 7-fluoro-3-methyltetral-1-one allowing aromatization of the naphthol intermediate, which is then oxidized into the corresponding 6-fluoromenadione. The multigram process has been demonstrated from 25 g of starting material scale with an improved overall yield of 50% and then applied to five other 7-substituted 3-methyltetralones and their corresponding 6-substituted menadiones.