3574-02-5

Basic information

• Product Name: 2-phenylnaphtho[1,2-d][1,3]oxazole
• Synonyms: 2-phenylnaphtho[1,2-d][1,3]oxazole
• CAS NO: 3574-02-5
• Molecular Formula: C₁₇H₁₁NO
• Molecular Weight: 245.27534
• Mol File: 3574-02-5.mol
• Article Data: 20

Chemical Properties

• Melting Point: 130-131 °C(Solv: water (7732-18-5); methanol (67-56-1))
• Boiling Point: 397°C at 760 mmHg
• Flash Point: 167°C
• Appearance: /
• Density: 1.232g/cm³
• Vapor Pressure: 3.75E-06mmHg at 25°C
• Refractive Index: 1.7
• PKA: 0.82±0.30(Predicted)
• CAS DataBase Reference: 2-phenylnaphtho[1,2-d][1,3]oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenylnaphtho[1,2-d][1,3]oxazole(3574-02-5)
• EPA Substance Registry System: 2-phenylnaphtho[1,2-d][1,3]oxazole(3574-02-5)

Safety Data

• Hazardous Substances Data: 3574-02-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C17H11NO/c1-2-7-13(8-3-1)17-18-16-14-9-5-4-6-12(14)10-11-15(16)19-17/h1-11H

Upstream product

• 72771-51-8 1-benzamido-2-naphthol 
• 40447-11-8 3-benzoyl-1-cyclohexyl-2-phenylaziridine 
• 131-91-9 1-Nitroso-2-naphthol 
• 1198-27-2 1-aminonaphthalene-2-ol hydrochloride 
• 100-52-7 benzaldehyde 
• 2834-92-6 1-amino-2-naphthol 
• 2211-61-2 trans-1-cyclohexyl-2-phenyl-3-benzoylaziridine 
• 4476-14-6 1,2-naphthoquinone-1-benzimide 
• 7629-77-8 2-phenyl-3H-naphtho[2,1-b][1,4]oxazin-3-one 
• 69321-38-6 1-nitroso-2-naphthol 
• 100-39-0 benzyl bromide 
• 15206-55-0 methyl 2-oxo-2-phenylacetate 
• 634-42-4 N-1-naphthalenyl-benzamide 
• 233-70-5 naphtho[1,2-d]oxazole 

Downstream Products

• 2834-92-6 1-amino-2-naphthol 
• 65-85-0 benzoic acid 

Relevant articles and documents

Chemodivergent Synthesis of Oxazoles and Oxime Ethers Initiated by Selective C-N/C-O Formation of Oximes and Diazo Esters

Chemodivergent reactions of oximes and diazo esters involving Rh-catalyzed [3+2] annulation and photodriven O-H insertion have been developed to generate oxazoles and oxime ethers. A range of aldehyde and ketone oximes reacted with α-diazocarbonyl compounds in a controllable manner in which functional groups, including ketone, ester, amide, ether, thiol ether, silane, alkene, allene, and alkyne groups, were well tolerated.

Visible Light-Induced Copper-Catalyzed C—H Arylation of Benzoxazoles?

A general method for visible light-induced copper-catalyzed arylation of sp2 C—H bonds of azoles has been developed. The method employs aryl halide as the coupling partner, lithium alkoxide as base. A variety of azoles including benzooxazole and benzothiazole can be arylated. Furthermore, electron-poor heterocycles such as thiophene possessing one electron-withdrawing group can also be arylated.

Iodine Promoted One-Pot Synthesis of 2-Aryl Benzoxazoles from Amidoximes via Oxidative Cyclization and Ring Contraction

A molecular I2-promoted one-pot synthesis of 2-aryl benzoxazoles has been developed by using amidoximes rather than the limited 2-aminophenols or 2-haloamides as substrates. The amidoxime substrates provided unique and efficient strategies for converting readily available aniline and benzaldehyde precursors into valuable chemicals. This transformation proceeded smoothly under transition-metal-free conditions through a sequential oxidative cyclization and ring contraction, and provided a potential route for introducing certain groups at any site of the scaffold.