3588-60-1 Usage
Description
N-CARBOBENZOXY-DL-LEUCINE is a biologically active amino acid that serves various purposes in different fields. It is commonly used as a nutritional supplement, flavor enhancer, and a component in the preparation of pharmaceutical and biochemical products such as amino acid infusions, comprehensive amino acid solutions, hypoglycemic agents, and plant growth promoters. Its ingestion as a part of a high whey protein, leucine-enriched supplement has been shown to increase postprandial muscle protein synthesis rates in healthy older individuals compared to conventional dairy products. This amino acid also exhibits significant anabolic properties, acting as a trigger for the initiation of protein synthesis and ensuring healthy human skeletal muscle metabolism. Furthermore, it may play a role in promoting plant growth.
Uses
Used in Nutritional Supplements:
N-CARBOBENZOXY-DL-LEUCINE is used as a nutritional supplement to support muscle protein synthesis and overall muscle health, particularly in older individuals.
Used in Pharmaceutical and Biochemical Products:
N-CARBOBENZOXY-DL-LEUCINE is used as a component in the preparation of amino acid infusions and comprehensive amino acid solutions, which are essential for various medical applications.
Used in Hypoglycemic Agents:
This amino acid is utilized in the development of hypoglycemic agents, which help regulate blood sugar levels in individuals with diabetes.
Used in Plant Growth Promotion:
N-CARBOBENZOXY-DL-LEUCINE is used as a plant growth promoter, potentially enhancing plant growth and development.
Used in Flavor Enhancement:
This amino acid is also employed as a flavor enhancer in the food industry, improving the taste and overall sensory experience of certain products.
Reference
Luiking, Y. C.; Deutz, N. E. P.; Memelink, R. G.; Verlaan, S.; Wolfe, R. R., Postprandial muscle protein synthesis is higher after a high whey protein, leucine-enriched supplement than after a dairy-like product in healthy older people: a randomized controlled trial. Nutr. J. 2014, 13, 14.
Wilkinson, D. J.; Hossain, T.; Hill, D. S.; Phillips, B. E.; Crossland, H.; Williams, J.; Loughna, P.; Churchward-Venne, T. A.; Breen, L.; Phillips, S. M.; Etheridge, T.; Rathmacher, J. A.; Smith, K.; Szewczyk, N. J.; Atherton, P. J., Effects of leucine and its metabolite -hydroxy--methylbutyrate on human skeletal muscle protein metabolism. J. Physiol.-London 2013, 591, 2911-2923.
Glick, B. R.; Todorovic, B.; Czarny, J.; Cheng, Z. Y.; Duan, J.; McConkey, B., Promotion of plant growth by bacterial ACC deaminase. Crit. Rev. Plant Sci. 2007, 26, 227-242.
Check Digit Verification of cas no
The CAS Registry Mumber 3588-60-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,5,8 and 8 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 3588-60:
(6*3)+(5*5)+(4*8)+(3*8)+(2*6)+(1*0)=111
111 % 10 = 1
So 3588-60-1 is a valid CAS Registry Number.
3588-60-1Relevant articles and documents
Chiral tetraaryl-and tetraalkynylborates as chiral solvating agents for tetraalkylammonium salts
Tayama, Eiji,Sugawara, Takeshi
supporting information, p. 803 - 811 (2019/01/18)
The application of tetracarbon-substituted chiral borate sodium salts (NaBR*4) as NMR chiral solvating agents for various tetraalkylammonium salts (R4NX) has been successfully demonstrated. Ion exchange between R4NX and NaBR*4 proceeded in excellent yields and provided the corresponding dia-stereomeric salts (R4NBR*4). The ee values of the R4NX salts were determined by1H NMR analysis of R4NBR*4. Two types of chiral borates, tetraaryl-and tetraalkynylborates with optically active 1,1′-binaphthyl components were used. At the beginning of this research, we investigated the efficacy of a known chiral tetraar-ylborate developed by Pommerening et al. for R4NX. To expand the possibility of further structural design of the chiral borate, we designed chiral tetraalkynylborates as a new structure. Their synthesis and application are also described.
Synthesis, screening and docking of small heterocycles as Glycogen Phosphorylase inhibitors
Schweiker, Stephanie S.,Loughlin, Wendy A.,Lohning, Anna S.,Petersson, Maria J.,Jenkins, Ian D.
, p. 584 - 594 (2015/03/14)
A series of morpholine substituted amino acids (phenylalanine, leucine, lysine and glutamic acid) was synthesized. A fragment-based screening approach was then used to evaluate a series of small heterocycles, including morpholine, oxazoline, dihydro-1,3-oxazine, tetrahydro-1,3-oxazepine, thiazoline, tetrahydro-1,3-pyrimidine, tetrahydro-1,3-diazepine and hexahydro-1H-benzimidazole, as potential inhibitors of Glycogen Phosphorylase a. Thiazoline 7 displayed an improved potency (IC50 of 25 μM) and had good LE and LELP values, as compared to heterocycles 1, 5, 9e13 and 19 (IC50 values of 1.1 mM e23.9 mM). A docking study using the crystal structure of human liver Glycogen Phosphorylase, provided insight into the interactions of heterocycles 5, 7, 9e13 and 19 with Glycogen Phosphorylase.
A Stereoselective entry into functionalized 1,2-diamines by zinc-mediated homologation of α-aminoacids
Hoang, Cam Thuy,Alezra, Valerie,Guillot, Regis,Kouklovsky, Cyrille
, p. 2521 - 2524 (2008/02/05)
A general, stereoselective synthsis of 4,5-disubstituted imidazolidines-2-ones from α-aminoacids has been developed: the key steps are a Biaise reaction of bromoacetate on α-aminonitriles and further reduction. Although reduction with sodium cyanoborohydride afforded a mixture of cis and trans isomers 6a-e with moderate to good stereoselectivity, reduction with sodium in liquid ammonia gave the trans isomers 8a-e with complete stereoselectivity. Acidic hydrolysis of the urea gave 4-amino-pyrrolidinones, which can be precursors to β,γ-diaminoacids or 3-aminopyrrolidines.
