3617-11-6Relevant articles and documents
Non-chelating p-phenylidene-linked bis-imidazoline analogs of known influenza virus endonuclease inhibitors: Synthesis and anti-influenza activity
Dar'in, Dmitry,Zarubaev, Vladimir,Galochkina, Anastasia,Gureev, Maxim,Krasavin, Mikhail
, p. 526 - 532 (2018/11/06)
A novel chemotype topologically similar to known influenza virus PA endonuclease inhibitors has been designed. It was aimed to reproduce the extended topology of the known metal-chelating ligands with a p-phenylidene-linked bis-imidazoline scaffold. It wa
Copper-catalyzed synthesis of 2-imidazolines and their N-hydroxyethyl derivatives under various conditions
Zhang, Jin,Wang, Xiao,Yang, Meipan,Wan, Kerou,Yin, Bing,Wang, Yunxia,Li, Jianli,Shi, Zhen
experimental part, p. 1578 - 1582 (2011/04/26)
A rapid and efficient method for the synthesis of 2-imidazolines and their N-hydroxyethyl derivatives from the reaction of aromatic nitriles with ethylenediamine (EDA) or N-(2-aminoethyl)ethanolamine (AEEA) using cupric indole-3-acetate (Cu(II)-(IAA)2) as a reusable catalyst under reflux and microwave conditions is reported. And seven new N-hydroxyethyl-imidazolines were reported for the first time.
Efficient catalytic synthesis of 2-imidazolines and bis-imidazolines with silica supported tungstosilicic acid
Nasr-Esfahani, Masoud,Montazerozohori, Morteza,Moghadam, Majid,Akhlaghia, Parisa
experimental part, p. 97 - 109 (2010/08/04)
A rapid and efficient preparation of 2-imidazolines and bis-imidazolines by the reaction of ethylenediamine or 1,2-propanediamine with nitriles in the presence of catalytic amounts of tungstosilicic acid supported on SiO 2 under reflux condition, is reported. The advantages of this procedure are moderate reaction times, good to high yields and the ability to carry out the large scale reactions. ARKAT USA, Inc.