36639-50-6

Basic information

• Product Name: 4-Nitrobenzenemethanesulfonic acid sodium salt
• Synonyms: 4-Nitrobenzenemethanesulfonic acid sodium salt;Sodium 4-nitrobenzenemethanesulfonate;Sodium 4-nitrobenzylsulfonate;Sodium (4-nitrophenyl)methanesulfonate;Sodium 4-nitrobenzylsulphonate
• CAS NO: 36639-50-6
• Molecular Formula: C₇H₆NO₅S*Na
• Molecular Weight: 239.18101
• Mol File: 36639-50-6.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-Nitrobenzenemethanesulfonic acid sodium salt(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Nitrobenzenemethanesulfonic acid sodium salt(36639-50-6)
• EPA Substance Registry System: 4-Nitrobenzenemethanesulfonic acid sodium salt(36639-50-6)

Safety Data

• Hazardous Substances Data: 36639-50-6(Hazardous Substances Data)

Usage

General Description

4-Nitrobenzenemethanesulfonic acid sodium salt, also known as Sodium 4-nitrobenzenesulfonate or SBSA, is a chemical compound with the molecular formula C7H6NNaO6S. It is a white to pale yellow solid that is soluble in water. SBSA is commonly used as an intermediate in the synthesis of various pharmaceuticals, dyes, and sulfonated aromatics. It is also used as a reducing agent in electroless plating and as a corrosion inhibitor in water treatment. SBSA is a versatile chemical that has a wide range of applications in different industries due to its solubility in water and its ability to act as a reducing agent and corrosion inhibitor.

Upstream product

• 100-14-1 4-nitrobenzyl chloride 
• 100-11-8 1-bromomethyl-4-nitro-benzene 

Downstream Products

• 88918-88-1 4-Amino-N,N-dimethylbenzenemethanesulphonamide 
• 88918-70-1 N,N-dimethyl-4-nitrobenzenemethanesulphonamide 
• 6387-28-6 (4-aminophenyl)methanesulfonic acid 
• 110654-58-5 1,3,5-Tris-(4-nitro-phenylmethanesulfonyl)-[1,3,5]triazinane 
• 110654-61-0 N-Methyl-N-{[methyl-(4-nitro-phenylmethanesulfonyl)-amino]-methyl}-C-(4-nitro-phenyl)-methanesulfonamide 
• 85952-29-0 (4-nitro-phenyl)-methanesulfonic acid methylamide 
• 88918-72-3 4-nitrobenzenemethanesulphonamide 
• 4025-75-6 (4-nitrophenyl)methanesulfonyl chloride 
• 803728-00-9 N,N-bis(2,4-dimethoxybenzyl)-1,1-difluoro-1-(4-nitrophenyl)methanesulfonamide 
• 803727-91-5 N,N-bis(2,4-dimethoxybenzyl)-1-(4-nitrophenyl)methanesulfonamide 
• 1064656-82-1 1-benzyl-3-(4-nitrophenyl)-3,4-dihydro-1H-2,1-benzothiazin-4-one 2,2-dioxide 

Relevant articles and documents

Olefination with Sulfonyl Halides and Esters: E-Selective Synthesis of Alkenes from Semistabilized Carbanion Precursors

Carbanions of sulfonyl halides and activated sulfonates add to carbonyl compounds, and so-formed aldol-type adducts spontaneously fragment into olefins. This transformation mimics the one-pot Julia olefination with (hetero)aryl sulfones, but the mechanism of fragmentation involves a four-membered intermediate, typical for reactivity of phosphorus reagents. Moreover, in contrast to the reactions of sulfones, sulfonates of fluorinated alcohols (TFE and HFI) produce byproducts that are easily removed during workup. In our report, we focus on reactions of unstabilized and semistabilized carbanion precursors: alkylsulfonates, and allyl- and benzylsulfonates, respectively. In particular for semistabilized systems, olefins were synthesized as predominant E isomers in good yields. The presented studies reveal that optimal reaction conditions, including the type of base and alcohol groups of the sulfonates, are different depending on stabilization of the carbanion precursors and structure of the carbonyl substrates. The practical synthetic guide is supplemented with a discussion of the mechanism, based on reactivity studies of intermediates and identification of side-products.

INDOLYLALKYL DERIVATIVES OF PYRIMIDINYLPIPERAZINE AND METABOLITES THEREOF FOR TREATMENT OF ANXIETY, DEPRESSION, AND SEXUAL DYSFUNCTION

The present invention relates to a method for alleviation, prevention, and treatment of anxiety, depression, and sexual dysfunction by administering certain indolylalkyl derivatives of pyrimidinylpiperazine or metabolites thereof. A preferred embodiment is of the following formula:

Synthesis of α-fluorosulfonamides by electrophilic fluorination

(Chemical Equation Presented) α-Fluorosulfonamides were prepared by electrophilic fluorination of tertiary sulfonamides using N- fluorobenzenesulfonimide as fluorinating agent and utilizing the dimethoxybenzyl group (DMB) as a new sulfonamide protecting g