366453-22-7

Basic information

• Product Name: 1H-Isoindol-1-one,2,3-dihydro-4-methoxy-(9CI)
• Synonyms: 1H-Isoindol-1-one,2,3-dihydro-4-methoxy-(9CI);1H-Isoindol-1-one, 2,3-dihydro-4-Methoxy-;4-Methoxy-2,3-dihydro-1H-isoindol-1-one;4-Methoxy-2,3-dihydro-isoindol-1-one
• CAS NO: 366453-22-7
• Molecular Formula: C₉H₉NO₂
• Molecular Weight: 163.175
• Product Categories: METHOXY
• Mol File: 366453-22-7.mol
• Article Data: 10

Chemical Properties

• Melting Point: >200 °C
• Boiling Point: 439.2±45.0 °C(Predicted)
• Appearance: /
• Density: 1.208±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.37±0.20(Predicted)
• CAS DataBase Reference: 1H-Isoindol-1-one,2,3-dihydro-4-methoxy-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindol-1-one,2,3-dihydro-4-methoxy-(9CI)(366453-22-7)
• EPA Substance Registry System: 1H-Isoindol-1-one,2,3-dihydro-4-methoxy-(9CI)(366453-22-7)

Safety Data

• Hazardous Substances Data: 366453-22-7(Hazardous Substances Data)

Usage

General Description

The chemical compound 1H-Isoindol-1-one,2,3-dihydro-4-methoxy-(9CI) is a derivative of isoindole with a dihydro-4-methoxy substituent. It is commonly used as a building block in the synthesis of various organic compounds and pharmaceuticals due to its versatile reactivity. The presence of the methoxy group makes this compound a potentially valuable intermediate for the preparation of bioactive molecules. Its chemical structure and properties make it an important target for research and development in the fields of organic chemistry and drug discovery. This chemical has the potential to serve as a key component in the production of numerous substances with a wide range of applications.

Upstream product

• 6850-57-3 2-methoxybenzylamine 
• 201230-82-2 carbon monoxide 
• 55289-06-0 3-methoxy-2-methylbenzoic acid 
• 42981-93-1 3-methoxy-2-methylbenzoic acid methyl ester 
• 71887-28-0 methyl 2-(bromomethyl)-3-methoxybenzoate 

Downstream Products

• 1263311-24-5 C₁₉H₁₉NO₄ 
• 366453-21-6 4-hydroxyisoindolin-1-one 

Relevant articles and documents

Ruthenium-Catalyzed Carbonylation of Oxalyl Amide-Protected Benzylamines with Isocyanate as the Carbonyl Source

An efficient synthesis of isoindolin-1-ones from oxalyl amide-protected benzylamines, through ruthenium-catalyzed intramolecular C(sp2)-H carbonylation, has been developed. Variously substituted benzylamines could be well tolerated in this new protocol, affording the corresponding products in moderate to excellent yields. This approach constitutes the first example of Ru(II)-catalyzed C(sp2)-H carbonylation with isocyanate as a novel commercially available carbonyl source.

Palladium-Catalyzed Direct C-H Carbonylation of Free Primary Benzylamines: A Synthesis of Benzolactams

A protocol for palladium-catalyzed C-H carbonylation of readily available free primary benzylamines using NH2 as the chelating group under an atmospheric pressure of CO has been achieved, providing a general, atom- and step-economic approach to

Design, synthesis, and structure-activity relationship studies of conformationally restricted mutilin 14-carbamates

We report herein the design, synthesis, and structure-activity relationship studies of conformationally restricted mutilin 14-carbamates based on the structure of SB-222734. The antibacterial activities of these newly synthesized compounds were also evaluated and compared with linezolid and retapamulin. Results showed that most of the target compounds exhibit good potency in inhibiting the growth of Gram-positive bacteria including Methicillin- susceptible Staphylococcus aureus MSSA (MIC: 0.0625-2 μg/mL), Methicillin-resistant S. aureus MRSA (MIC: 0.0625-2 μg/mL), Methicillin-susceptible Staphylococcus epidermidis MSSE (MIC: 0.0625-2 μg/mL), Methicillin-resistant S. epidermidis MRSE (MIC: 0.0625-2 μg/mL), and Streptococcus pneumonia (MIC: 0.0625-4 μg/mL). In particular, three remarkable compounds of this series (12l, 12m, and 21l) exhibited comparable in vitro antibacterial profiles to that of retapamulin.