36895-36-0

Basic information

• Product Name: 7-((3-phenylisoxazol-5-yl)methoxy)-4-methyl-2H-benzopyran-2-one
• Synonyms: 7-((3-phenylisoxazol-5-yl)methoxy)-4-methyl-2H-benzopyran-2-one
• CAS NO: 36895-36-0
• Molecular Weight: 333.343
• Mol File: 36895-36-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 7-((3-phenylisoxazol-5-yl)methoxy)-4-methyl-2H-benzopyran-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-((3-phenylisoxazol-5-yl)methoxy)-4-methyl-2H-benzopyran-2-one(36895-36-0)
• EPA Substance Registry System: 7-((3-phenylisoxazol-5-yl)methoxy)-4-methyl-2H-benzopyran-2-one(36895-36-0)

Safety Data

• Hazardous Substances Data: 36895-36-0(Hazardous Substances Data)

Upstream product

• 2039-50-1 5-bromomethyl-3-phenyl-isoxazole 
• 108-46-3 recorcinol 
• 100-52-7 benzaldehyde 
• 932-90-1 Benzaldoxime 
• 90924-12-2 3-phenyl-5-hydroxymethylisoxazole 
• 67268-43-3 7-propargyloxy-4-methyl-2H-chromen-2-one 
• 698-16-8 benzohydroximoyl chloride 
• 90-33-5 7-hydroxy-4-methyl-chromen-2-one 
• 3993-57-5 7-allyloxy-4-methyl-2H-chromen-2-one 
• 873-67-6 benzonitrile oxide 
• 36895-28-0 4-methyl-7-((3-phenyl-4,5-dihydroisoxazol-5-yl)methoxy)-2Hchromen-2-one 

Relevant articles and documents

Synthesis and in vitro biological evaluation of novel coumarin derivatives containing isoxazole moieties on melanin synthesis in B16 cells and inhibition on bacteria

A novel series of coumarin derivatives 6a–o, bearing isoxazole moieties were designed and synthesized. After that, they were evaluated for melanin synthesis in murine B16 cells and inhibitory effect on the growth of CA (Candida albicans), EC (Escherichia coli), SA (Staphylococcus aureus). It was found that eleven compounds (6b–f, 6j–o) showed a better activity on melanin synthesis than positive control (8-MOP). Among them, compounds 6d (242%) and 6f (390%), with nearly 1.6 and 2.6-fold potency compared with 8-MOP (149%) respectively, were recognized as the most promising candidate hits for further pharmacological study of anti-vitiligo. Seven halogen substituted compounds exhibited moderate antimicrobial activity against CA. It is interesting that 6e–f and 6l–m, which had two halogens on the benzene showed a comparable activity with Amphotericin B against CA. The evaluation of melanin synthesis in B16 cells and inhibitory effect on bacteria of above structurally diverse derivatives had also led to an outline of structure-activity relationship.

Design and synthesis of antimicrobial, anticoagulant, and anticholinesterase hybrid molecules from 4-methylumbelliferone

We designed and synthesized new series of diverse triazoles, isoxazoles, isoxazolines, and aziridines linked 4-methylumbelliferone 1 using intermolecular 1,3-dipolar cycloaddition reactions. Structures of these compounds were established on the basis of 1H NMR, 13C NMR, and ESI-HRMS. All prepared compounds were evaluated for their antimicrobial, anticoagulant, and anticholinesterase activities. Interestingly, among the tested molecules, some of the analogs displayed better activities than the parent 4-methylumbelliferone 1 such as 6a and 6d for their antifungal properties. Moreover, compounds 4, 5, 6, and 7 showed the importance of the added fragments to 4-methylumbelliferone 1 via the linker methylene to have good activity.