36983-36-5

Basic information

• Product Name: ETHYL 2,4-DIOXO-4-(2-THIENYL)BUTANOATE
• Synonyms: AKOS MSC-0268;ETHYL 2,4-DIOXO-4-(2-THIENYL)BUTANOATE;Ethyl 2,4-dioxo-4-(2-thienyl)butanoate, 90+%;ETHYL 3-(2-THENOYL)PYRUVATE;Ethyl 2,4-dioxo-4-(thien-2-yl)butanoate;2,4-Dioxo-4-thiophen-2-yl-butyric acid ethyl ester
• CAS NO: 36983-36-5
• Molecular Formula: C₁₀H₁₀O₄S
• Molecular Weight: 226.25
• Mol File: 36983-36-5.mol
• Article Data: 20

Chemical Properties

• Melting Point: 34°C
• Boiling Point: 375.9°Cat760mmHg
• Flash Point: 181.1°C
• Appearance: /
• Density: 1.277g/cm³
• Vapor Pressure: 7.52E-06mmHg at 25°C
• Refractive Index: 1.533
• CAS DataBase Reference: ETHYL 2,4-DIOXO-4-(2-THIENYL)BUTANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2,4-DIOXO-4-(2-THIENYL)BUTANOATE(36983-36-5)
• EPA Substance Registry System: ETHYL 2,4-DIOXO-4-(2-THIENYL)BUTANOATE(36983-36-5)

Safety Data

• Hazard Codes: Xi
• Safety Statements: S24/25:Avoid contact with skin and eyes.
• HazardClass: IRRITANT
• Hazardous Substances Data: 36983-36-5(Hazardous Substances Data)

Usage

General Description

ETHYL 2,4-DIOXO-4-(2-THIENYL)BUTANOATE is a chemical compound with the molecular formula C9H8O4S. It is an ester with a thienyl group and two carbonyl groups attached to the butanoate chain. ETHYL 2,4-DIOXO-4-(2-THIENYL)BUTANOATE is commonly used in organic synthesis and pharmaceutical research as a building block for the creation of more complex molecules. It is also known for its potential applications in the development of new drugs and materials. Additionally, it is important to handle this chemical with care, following all safety protocols and guidelines, due to its potential hazards and risks associated with its use.

InChI:InChI=1/C10H10O4S/c1-2-14-10(13)8(12)6-7(11)9-4-3-5-15-9/h3-5H,2,6H2,1H3

Upstream product

• 88-15-3 2-Acetylthiophene 
• 95-92-1 oxalic acid diethyl ester 
• 5370-25-2 2-Acetyl-5-bromothiophene 

Downstream Products

• 133765-13-6 3-[(4-Chloro-phenyl)-hydrazono]-2,4-dioxo-4-thiophen-2-yl-butyric acid ethyl ester 
• 465514-11-8 5-(2-thienyl)isoxazole-3-carbaldehyde 
• 194491-44-6 [5-(2-thienyl)isoxazol-3-yl]methanol 
• 90924-54-2 ethyl 5-(2-thiophenyl)-isoxazole-3-carboxylate 
• 876316-46-0 1-methyl-5-thien-2-yl-1H-pyrazole-3-carbonyl chloride 
• 121195-03-7 ethyl 3-(thiophen-2-yl)-1H-pyrazole-5-carboxylate 
• 1601484-32-5 5-bromo-2-[2,4-dioxo-4-(thiophen-2-yl)butanamido]benzoic acid 
• 1601484-31-4 2-[2,4-dioxo-4-(thiophen-2-yl)butanamido]benzoic acid 
• 1227958-20-4 ethyl 5-(thiophen-2-yl)-1-(3,4,5-trimethoxyphenyl)-pyrazole-3-carboxylate 
• 133765-20-5 1-{5-[3-(3,4-Dimethyl-phenyl)-6-oxo-1-phenyl-1,4,5,6-tetrahydro-pyridazin-4-ylsulfanyl]-2H-[1,2,4]triazol-3-yl}-3-thiophen-2-yl-propane-1,3-dione 
• 133765-17-0 2-Cyano-3-[5-(3-oxo-3-thiophen-2-yl-propionyl)-1H-[1,2,4]triazol-3-ylsulfanyl]-3-phenyl-propionic acid ethyl ester 
• 133765-18-1 4-(3,4-Dimethyl-phenyl)-4-oxo-2-[5-(3-oxo-3-thiophen-2-yl-propionyl)-1H-[1,2,4]triazol-3-ylsulfanyl]-butyric acid 

Relevant articles and documents

Hybrid organoruthenium(II) complexes with thiophene-β-diketo-benzazole ligands: Synthesis, optical properties, CT-DNA interactions and anticancer activity

Two new hybrid half‐sandwiched Ru(II) arene complexes of a general formula [η6-(p-cymene)Ru(L)Cl] (4a,b) {where L = 1-(Benzazol-2-yl)-3-(thiophen-2-yl) propane-1,3-dione} were synthesized and characterized. Spectral and elemental analysis revealed that these complexes have tetrahedral piano stool‐like geometry with a coordination environment composed of two O atoms of ligand, chloride ion, and electron cloud of p‐cymene moiety. The CT-DNA–Ru(II) complexes interactions were evaluated based on absorption and emission titration experiments. The results have shown intercalative modes of interaction between DNA and complexes, with a preferable binding to complex 4b. Based on the in vitro cytotoxicity MTT assay, the complexes exhibit significant inhibitory activity against human breast and lung cancer cells (MCF-7, A549), with lower micromolar IC50 values in comparison to that of clinical drug (cisplatin). In contrast, neither complex shows activity against the normal cell lines (Hela), suggesting that the new hybrid thiophene-β-diketo-benzazole organoruthenium(II) complexes may offer promising safe anticancer agents.

Synthesis, characterization, thermal analysis and biological study of new thiophene derivative containing o-aminobenzoic acid ligand and its mn(ii), cu(ii) and co(ii) metal complexes

New ligand containing 2-(2,4-dioxo-4-thiophen-2-yl-butyrylamino)-benzoic acid (HL) merged moiety was synthesized and characterized by FT-IR, elemental analyses, mass spectra and 1H-NMR spectral. In the present study, the attempts were carried to form comp

ISOXAZOLE CARBOXAMIDE COMPOUNDS AND USES THEREOF

A compound of Formula (I) or or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating hearing loss or balance disorder: Formula (I) wherein R1 and Y are as defined herein.