371252-55-0

Basic information

• Product Name: 2,2'-((3S,3'S)-1,1'-dibenzyl-2,2'-dioxo-[3,3'-biindoline]-3,3'-diyl)diacetaldehyde
• Synonyms: 2,2'-((3S,3'S)-1,1'-dibenzyl-2,2'-dioxo-[3,3'-biindoline]-3,3'-diyl)diacetaldehyde
• CAS NO: 371252-55-0
• Molecular Weight: 528.607
• Mol File: 371252-55-0.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2,2'-((3S,3'S)-1,1'-dibenzyl-2,2'-dioxo-[3,3'-biindoline]-3,3'-diyl)diacetaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2'-((3S,3'S)-1,1'-dibenzyl-2,2'-dioxo-[3,3'-biindoline]-3,3'-diyl)diacetaldehyde(371252-55-0)
• EPA Substance Registry System: 2,2'-((3S,3'S)-1,1'-dibenzyl-2,2'-dioxo-[3,3'-biindoline]-3,3'-diyl)diacetaldehyde(371252-55-0)

Safety Data

• Hazardous Substances Data: 371252-55-0(Hazardous Substances Data)

Upstream product

• 1431511-03-3 C₂₅H₂₀N₂O₂ 
• 1431510-70-1 C₃₆H₃₄N₂O₅ 
• 1431510-69-8 C₃₇H₃₆N₂O₄ 
• 1431510-68-7 C₃₄H₃₂N₂O₄ 
• 1431510-66-5 C₃₄H₃₂N₂O₃ 
• 1431511-04-4 C₂₇H₂₆N₂O₃ 
• 120-72-9 indole 
• 13672-10-1 (Z)-2-(1-benzyl-2-oxoindolin-3-ylidene)acetaldehyde 
• 247061-32-1 (4S,5S)-4,5-Bis-benzyloxy-cyclohex-1-ene-1,2-dicarboxylic acid bis-[benzyl-(2-iodo-phenyl)-amide] 
• 247061-38-7 (3aS,7aS)-2,2-Dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxole-5,6-dicarboxylic acid bis-[benzyl-(2-iodo-phenyl)-amide] 
• 247061-33-2 (4S,5S)-4,5-Dihydroxy-cyclohex-1-ene-1,2-dicarboxylic acid bis-[benzyl-(2-iodo-phenyl)-amide] 
• 247061-31-0 (4S,5S)-4,5-Bis-benzyloxy-cyclohex-1-ene-1,2-dicarboxylic acid bis-[(2-iodo-phenyl)-amide] 
• 247061-39-8 C₃₇H₃₂N₂O₄ 
• 615-43-0 2-iodophenylamine 

Downstream Products

• 595-05-1 Calycanthin 
• 247061-42-3 C₃₄H₃₂N₈O 
• 247061-43-4 C₃₄H₃₆N₄O 
• 247061-41-2 C₃₄H₃₄N₂O₃ 
• 247061-44-5 8,8'-dibenzyl-2,3,8,8a,2',3',8',8'a-octahydro-1H,1'H-[3a,3'a]bi[pyrrolo[2,3-b]indolyl] 
• 247061-45-6 8,8'-dibenzyl-1,1'-dimethyl-2,3,8,8a,2',3',8',8'a-octahydro-1H,1'H-[3a,3'a]bi[pyrrolo[2,3-b]indolyl] 
• 371252-68-5 C₈₂H₉₂N₆O₈Si₂ 
• 371252-69-6 C₇₂H₆₈N₆O₈ 
• 371252-59-4 (3S,3'S)-3,3'-Bis-[(R)-2-azido-3-(2-trimethylsilanyl-ethoxy)-propyl]-1,1'-dibenzyl-1,3,1',3'-tetrahydro-[3,3']biindolyl-2,2'-dione 
• 371252-66-3 (3S,3'S)-3,3'-Bis-[(S)-2-azido-3-(2-trimethylsilanyl-ethoxy)-propyl]-1,1'-dibenzyl-1,3,1',3'-tetrahydro-[3,3']biindolyl-2,2'-dione 
• 371252-65-2 (3S,3'S)-1,1'-Dibenzyl-3,3'-bis-[(R)-2-hydroxy-3-(2-trimethylsilanyl-ethoxy)-propyl]-1,3,1',3'-tetrahydro-[3,3']biindolyl-2,2'-dione 
• 371252-67-4 (2S,3aS,8aR,2'S,3'aS,8'aR)-8,8'-Dibenzyl-2,2'-bis-(2-trimethylsilanyl-ethoxymethyl)-2,3,8,8a,2',3',8',8'a-octahydro-1H,1'H-[3a,3'a]bi[pyrrolo[2,3-b]indolyl] 
• 371252-60-7 (2R,3aS,8aR,2'R,3'aS,8'aR)-8,8'-Dibenzyl-2,2'-bis-(2-trimethylsilanyl-ethoxymethyl)-2,3,8,8a,2',3',8',8'a-octahydro-1H,1'H-[3a,3'a]bi[pyrrolo[2,3-b]indolyl] 
• 371252-64-1 (3S,3'S)-1,1'-Dibenzyl-3,3'-bis-[2-oxo-3-(2-trimethylsilanyl-ethoxy)-propyl]-1,3,1',3'-tetrahydro-[3,3']biindolyl-2,2'-dione 

Relevant articles and documents

Phosphine-Catalyzed (3+2) Annulation of Isoindigos with Allenes: Enantioselective Formation of Two Vicinal Quaternary Stereogenic Centers

Construction of contiguous all-carbon quaternary stereogenic centers is a long-standing challenge in synthetic organic chemistry. In this report, a phosphine-catalyzed enantioselective (3+2) annulation reaction between allenes and isoindigos, containing either two identical or different oxindole moieties, is introduced as a powerful strategy for the construction of spirocyclic bisindoline alkaloid core structures. The reported reactions feature high chemical yields, excellent enantioselectivities, and very good regioselectivities, and are highly useful for creating structurally challenging bisindoline natural products.

Catalytic Enantioselective Decarboxylative Allylations of a Mixture of Allyl Carbonates and Allyl Esters: Total Synthesis of (-)- and (+)-Folicanthine

A highly enantioselective decarboxylative allylation of a mixture of enol carbonates and allyl esters has been achieved. The strategic viability of this methodology has been demonstrated through the total synthesis of cyclotryptamine alkaloids (-)- and (+)-folicanthine (1 a) and the formal total synthesis of (-)-chimonanthine (1 b), (+)-calycanthine (1 c), and (-)-ditryptophenaline (1 d).

Palladium-catalyzed asymmetric construction of vicinal all-carbon quaternary stereocenters and its application to the synthesis of cyclotryptamine alkaloids

A twofold Pd-DAAA Pd-catalyzed decarboxylative allylic alkylation (see scheme) was used to construct two vicinal all-carbon quaternary stereocenters (marked in red) in a diastereo- and enantioselective fashion. The products of the Pd-DAAA were further ela