3730-54-9

Basic information

• Product Name: 2-(Diethoxyphosphinyl)-3-oxobutanoic acid ethyl ester
• Synonyms: 2-(Diethoxyphosphinyl)-3-oxobutanoic acid ethyl ester;ENT-25623;SD-2580;Shell SD-2580
• CAS NO: 3730-54-9
• Molecular Formula: C₁₀H₁₉O₆P
• Molecular Weight: 266.26
• Mol File: 3730-54-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 343.2°C at 760 mmHg
• Flash Point: 175.1°C
• Appearance: /
• Density: 1.15g/cm³
• Vapor Pressure: 7.15E-05mmHg at 25°C
• Refractive Index: 1.435
• CAS DataBase Reference: 2-(Diethoxyphosphinyl)-3-oxobutanoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Diethoxyphosphinyl)-3-oxobutanoic acid ethyl ester(3730-54-9)
• EPA Substance Registry System: 2-(Diethoxyphosphinyl)-3-oxobutanoic acid ethyl ester(3730-54-9)

Safety Data

• Hazardous Substances Data: 3730-54-9(Hazardous Substances Data)

Usage

Uses

Agricultural chemical.

Hazard

A poison by ingestion.

InChI:InChI=1/C10H19O6P/c1-5-14-10(12)9(8(4)11)17(13,15-6-2)16-7-3/h9H,5-7H2,1-4H3

Upstream product

• 84911-18-2 ethyl 2-bromoacetoacetate 
• 122-52-1 triethyl phosphite 
• 75-36-5 acetyl chloride 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 108-24-7 acetic anhydride 
• 589-57-1 diethyl phosphorylchloridite 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 1067-71-6 Diethyl (2-oxopropyl)phosphonate 
• 1609669-94-4 diethyl (5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)phosphonate 
• 1609670-01-0 diethyl (1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)phosphonate 

Relevant articles and documents

The surprising diacylation of diethyl (ethoxycarbonylmethyl)phosphonate

Deprotonation of diethyl (ethoxycarbonylmethyl)-phosphonate with NaH followed by treatment with acyl chlorides affords surprisingly the corresponding C,C-diacylated derivatives as the predominating products.

A simplified synthesis of the diastereomers of Levuglandin E2

We report a synthesis of Levuglandin E2, as a mixture of easily separable diastereomers (15-E2-isoketals). The key feature is the protection of its reactive aldehyde as dimethyl acetal, which is introduced with 2,2-dimethoxyethanal and removed in minutes with Montmorillonite K-10. The synthesis could be modified to the preparation of 15-E2-isoketals with stable isotopes or with radiolabels. Copyright Taylor & Francis, Inc.

On a safe and practical method for the preparation of β-keto phosphonates

Acylations of the magnesium enolate derivatives of trimethyl and triethylphosphonoacetates, using a magnesium chloride-triethylamine system, lead to 2-acetylphosphonoacetates which are decarbalkoxylated to give β-keto phosphonates.