3743-28-0Relevant articles and documents
Practical Chemoselective Acylation: Organocatalytic Chemodivergent Esterification and Amidation of Amino Alcohols with N-Carbonylimidazoles
Brown, Hailee,Heller, Stephen T.,Light, Christina,Medlin, Abigail,Nelson, Hope,Richard, William
supporting information, p. 22818 - 22825 (2021/09/13)
Chemoselective transformations are a cornerstone of efficient organic synthesis; however, achieving this goal for even simple transformations, such as acylation reactions, is often a challenge. We report that N-carbonylimidazoles enable catalytic chemodivergent aniline or alcohol acylation in the presence of pyridinium ions or 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), respectively. Both acylation reactions display high and broad chemoselectivity for the target group. Unprecedented levels of chemoselectivity were observed in the DBU-catalyzed esterification: A single esterification product was obtained from a molecule containing primary aniline, alcohol, phenol, secondary amide, and N?H indole groups. These acylation reactions are highly practical as they involve only readily available, inexpensive, and relatively safe reagents; can be performed on a multigram scale; and can be used on carboxylic acids directly by in situ formation of the acylimidazole electrophile.
Novel 3/4-((Substitutedbenzamidophenoxy)methyl)-N-hydroxybenzamides/propenamides and its use
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Paragraph 0101; 0103; 0104, (2020/03/17)
The present invention relates to novel 3/4-((substituted benzamidophenoxy) methyl) -N-hydroxy benzamide/propenamide, as a histone deacetylase (HDAC) inhibitor, and to an anticancer composition comprising the same as an active ingredient. More specifically
Amide type phytoalexin compound and preparation method thereof and whitening cosmetic composition containing it
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Paragraph 0071-0074, (2019/02/16)
The present invention relates to a phytoalexin compound having an amide structure represented by chemical formula 1, a production method thereof, and a whitening cosmetic composition containing the same. In the chemical formula 1, R_1 and R_2 are hydrogen, R_1 is hydroxy, and R_2 is hydrogen, or R_1 and R_2 are hydroxy.COPYRIGHT KIPO 2019