37559-54-9

Basic information

• Product Name: [2,2,2-trifluoro-1-methoxy-1-(trifluoromethyl)ethyl]benzene
• Synonyms: [2,2,2-trifluoro-1-methoxy-1-(trifluoromethyl)ethyl]benzene
• CAS NO: 37559-54-9
• Molecular Weight: 258.163
• Mol File: 37559-54-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: [2,2,2-trifluoro-1-methoxy-1-(trifluoromethyl)ethyl]benzene(CAS DataBase Reference)
• NIST Chemistry Reference: [2,2,2-trifluoro-1-methoxy-1-(trifluoromethyl)ethyl]benzene(37559-54-9)
• EPA Substance Registry System: [2,2,2-trifluoro-1-methoxy-1-(trifluoromethyl)ethyl]benzene(37559-54-9)

Safety Data

• Hazardous Substances Data: 37559-54-9(Hazardous Substances Data)

Upstream product

• 66-27-3 Methyl methanesulfonate 
• 718-64-9 1,1,1,3,3,3-hexafluoro-2-phenylisopropyl alcohol 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 
• 67-56-1 methanol 
• 32133-82-7 Martins sulfurane 

Downstream Products

• 423-02-9 perfluoro isopropyl cyclohexane 

Relevant articles and documents

Liquid-phase photofluorination with elemental fluorine. Part III. Synthesis of perfluorocycloalkyl ethers with/without a chlorine substituent

Liquid-phase photofluorination (LPPF) of 2-phenyl-2-methoxyhexafluoropropane 1 gave the desired F-2-cyclohexyl-2-methoxypropane, 2, in 21percent yield.An unusual rearranged product, F-2-cyclohexylmethyl isopropyl ether, 4, and a degradation product, F-2-cyclohexylpropane, 3, were also produced in 10 and 20percent yields, respectively.A plausible reaction mechanism for the formation of the rearranged product 4 was presented.The Cl-containing ethers with cyclic structures, 2-chlorohexafluorocyclopentenyl cyclopentyl ether, and 2-chlorohexafluorocyclopentenyl 2,2,3,3,4,4,5,5-octafluoro-n-pentyl ether were also perfluorinated by the LPPF method to give the corresponding Cl-containing F-ethers in fair yields.The total retention of the chlorine atom through perfluorination and the ability to have a benzene substituent on the substrate are beneficial features of this novel perfluorinating method. - Keywords: Liquid-phase photofluorination; Perfluorocycloalkyl ethers; GC-MS; 19F-NMR

Practice of fluorous biphase chemistry: Convenient synthesis of novel fluorophilic ethers via a Mitsunobu reaction

The evolution of the term fluorous is addressed first, then a concise terminology is proposed, including fluorous partition coefficient, specific fluorophilicity and fluorousness. Some examples are shown for the design of higher generation fluorophilic mo